LOW-NICKEL DIET AS A STRATEGY IN THE TREATMENT OF HELICOBACTER PYLORI INFECTION.

Q2 Medicine

Arquivos de Gastroenterologia Pub Date : 2025-07-21 eCollection Date: 2025-01-01 DOI:10.1590/S0004-2803.24612024-108

Beatriz Soares Brito, Felipe Ferreira Ribeiro de Souza, Daniel Machado Baptista, Rafael Bandeira Lages, Ricardo Correa Barbuti, Tomás Navarro-Rodriguez

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引用次数: 0

Abstract

Context: The rising antibiotic resistance in Helicobacter pylori (H. pylori) infection have made treatment more challenging. A low-nickel diet may improve eradication rates based on the bacteria's mechanisms.

Objective: This study aimed to evaluate the effect of a low-nickel diet during standard triple therapy on the rate of H. pylori eradication.

Methods: This randomized clinical trial included patients with H. pylori infection who were classified into the following two groups: low-nickel diet and regular diet. Both groups received the standard triple therapy with amoxicillin, clarithromycin, and a proton pump inhibitor. After at least 8 weeks of treatment, a control test for H. pylori was performed.

Results: Per-protocol analysis showed a higher rate of H. pylori eradication in the low-nickel diet group than in the regular diet group (91.7% vs 75.8%; P=0.026). In addition, obesity was associated with poorer eradication rates (73.2% vs 88.9%, P=0.038). Patients on a low-nickel diet were 3.41 times (1.21-11.40) more likely to have H. pylori eradication than those on a normal diet.

Conclusion: This study showed that low-nickel diet, which is a low-cost and low-risk intervention, may be an appropriate strategy for increasing H. pylori eradication rates.

Background: • Evaluate the effect of low-nickel diet during standard triple therapy on the rate of Helicobacter pylori eradication.

Background: • This randomized clinical trial included patients infected with Helicobacter pylori in groups with a low-nickel nickel or regular diet, who underwent standard triple therapy and the efficacy of bacterial eradication was compared between both groups.

Background: • Per-protocol analysis showed a higher rate of Helicobacter pylori eradication in the low-nickel diet group than in the regular diet group (91.7% vs 75.8%; P=0.026).

Background: • The low-nickel diet is an appropriate strategy for increasing Helicobacter pylori eradication rates.

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低镍饮食作为治疗幽门螺杆菌感染的策略。

背景：幽门螺杆菌（h.p ylori）感染的抗生素耐药性上升使治疗更具挑战性。根据细菌的机制，低镍饮食可能会提高根除率。目的：本研究旨在评价标准三联治疗期间低镍饮食对幽门螺杆菌根除率的影响。方法：将幽门螺杆菌感染患者随机分为低镍饮食组和常规饮食组。两组均接受阿莫西林、克拉霉素和质子泵抑制剂的标准三联治疗。治疗至少8周后，进行幽门螺杆菌对照试验。结果：按方案分析显示，低镍饮食组幽门螺杆菌根除率高于常规饮食组(91.7% vs 75.8%；P = 0.026)。此外，肥胖与较差的根除率相关（73.2% vs 88.9%， P=0.038）。低镍饮食的患者幽门螺杆菌根除的可能性是正常饮食患者的3.41倍（1.21-11.40）。结论：低镍饮食是一种低成本、低风险的干预措施，可能是提高幽门螺杆菌根除率的合适策略。•评估标准三联治疗期间低镍饮食对幽门螺杆菌根除率的影响。背景：•本随机临床试验纳入了低镍组和常规饮食组的幽门螺杆菌感染患者，他们接受了标准的三联疗法，并比较了两组之间的细菌根除效果。背景：•按方案分析显示，低镍饮食组幽门螺杆菌根除率高于常规饮食组(91.7% vs 75.8%；P = 0.026)。背景：•低镍饮食是提高幽门螺杆菌根除率的适当策略。

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来源期刊

Arquivos de Gastroenterologia Medicine-Gastroenterology

CiteScore

2.00

自引率

0.00%

发文量

109

审稿时长

9 weeks

期刊介绍： The journal Arquivos de Gastroenterologia (Archives of Gastroenterology), a quarterly journal, is the Official Publication of the Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia IBEPEGE (Brazilian Institute for Studies and Research in Gastroenterology), Colégio Brasileiro de Cirurgia Digestiva - CBCD (Brazilian College of Digestive Surgery) and of the Sociedade Brasileira de Motilidade Digestiva - SBMD (Brazilian Digestive Motility Society). It is dedicated to the publishing of scientific papers by national and foreign researchers who are in agreement with the aim of the journal as well as with its editorial policies.