Antimicrobial management of complex biofilms in diabetic foot ulcers: a microbiological perspective.

IF 3.8 2区 医学 Q1 INFECTIOUS DISEASES
Manuela Oliveira, Eva Cunha, Luís Tavares, Isa Serrano
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引用次数: 0

Abstract

Introduction: Diabetic foot ulcers (DFUs) are a significant health concern, often complicated by biofilm formation which delays healing and increases the risk of diabetic foot infections (DFIs). Effective management of complex biofilms is crucial for improving patient outcomes and reducing the risk of amputation and premature death.

Areas covered: This review summarizes the current state of microbiological research on DFIs, focusing on bacterial populations, biofilm interactions, and their role in antibiotic resistance development, being based on a PubMed search from 1975 to 2025. It also explores recent advances in antimicrobial therapies, including phage therapy, antimicrobial peptides, and other novel treatments.

Expert opinion: Antimicrobial stewardship, broader access to medical resources, and improved sanitation are essential to diminish the impact of diabetes on healthcare systems. Furthermore, the development of a rapid tool to detect antibiotic-tolerant cells is fundamental to avoid DFIs relapse. The biofilms dynamics and the dual relationship between biofilms and the immune system should be further understood. While traditional antibiotics are essential to treat DFIs, a multi-combinatorial strategy combining conventional compounds with alternative therapies should be more effective to overcome resistance and promote wound healing in DFUs.

糖尿病足溃疡复杂生物膜的抗菌管理:微生物学观点。
导读:糖尿病足溃疡(DFUs)是一个重要的健康问题,通常因生物膜形成而复杂化,从而延迟愈合并增加糖尿病足感染(dfi)的风险。复杂生物膜的有效管理对于改善患者预后和降低截肢和过早死亡的风险至关重要。涵盖领域:本综述总结了DFIs微生物学研究的现状,重点是细菌种群、生物膜相互作用及其在抗生素耐药性发展中的作用,基于1975年至2025年的PubMed检索。它还探讨了抗微生物疗法的最新进展,包括噬菌体疗法、抗微生物肽和其他新疗法。专家意见:抗菌药物管理、更广泛地获得医疗资源和改善卫生条件对于减少糖尿病对卫生保健系统的影响至关重要。此外,开发一种快速检测耐抗生素细胞的工具是避免dfi复发的基础。生物膜动力学以及生物膜与免疫系统的双重关系有待进一步认识。虽然传统抗生素对治疗dfi至关重要,但将传统药物与替代疗法相结合的多组合策略应该更有效地克服耐药并促进dfu的伤口愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
66
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
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