Tear and blood salusin-α, and -β, copeptin, and asprosin in patients with glaucoma and ocular hypertension.

IF 1.2 4区 医学 Q3 OPHTHALMOLOGY
Arquivos brasileiros de oftalmologia Pub Date : 2025-07-21 eCollection Date: 2025-01-01 DOI:10.5935/0004-2749.2024-0230
Sermal Arslan, Mehmet Kaan Kaya, Süleyman Aydin
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引用次数: 0

Abstract

Purpose: This pilot study was conducted to investigate the presence of various bioactive compounds (copeptin, asprosin, and salusins) in the blood and tears of patients with glaucoma.

Methods: A total of 83 subjects, including 28 patients with open-angle glaucoma, 28 patients with ocular hypertension, and 27 control volunteers, were enrolled in this study. The levels of salusin-α, salusin-β, copeptin, and asprosin in tears and venous blood samples were measured by enzyme linked immunosorbent assay (ELISA).

Results: Patients with open-angle glaucoma and those with ocular hypertension showed statistically significantly decreased levels of salusin-α and salusin-β in their blood and tears compared with those of control subjects (p<0.05), with the decrease being the most pronounced in patients with ocular hypertension (p<0.05). In contrast, the levels of copeptin and asprosin showed a statistically significant increase in both these patient groups compared with those of control subjects (p<0.05). There was a negative correlation between intraocular pressure and blood and tear salusins.

Conclusions: Fluids from patients with open-angle glaucoma and ocular hypertension showed lower salusin levels. Patients with ocular hypertension had higher levels of copeptin and asprosin, but not those with open-angle glaucoma (except for asprosin, whose levels showed a slight but remarkable increase in plasma in patients with open-angle glaucoma). The pathogenesis of ocular hypertension and open-angle glaucoma may be significantly impacted by these biomarkers.

青光眼和高眼压患者的泪液和血salusin-α、-β、copeptin和asprosin。
目的:本初步研究旨在探讨青光眼患者血液和泪液中多种生物活性化合物(copeptin、asprosin和salusins)的存在。方法:共83例受试者,其中开角型青光眼患者28例,高眼压患者28例,对照组27例。采用酶联免疫吸附法(ELISA)测定小鼠泪液和静脉血中salusin-α、salusin-β、copeptin和asprosin的含量。结果:与对照组相比,开角型青光眼和高眼压患者的血液和泪液中salusin-α和salusin-β水平明显降低(p结论:开角型青光眼和高眼压患者的液体中salusin水平较低)。高眼压患者有较高的copeptin和asprosin水平,而开角型青光眼患者没有(asprosin除外,开角型青光眼患者血浆中asprosin水平有轻微但显著的升高)。高眼压和开角型青光眼的发病机制可能受到这些生物标志物的显著影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
200
审稿时长
6-12 weeks
期刊介绍: The ABO-ARQUIVOS BRASILEIROS DE OFTALMOLOGIA (ABO, ISSN 0004-2749 - print and ISSN 1678-2925 - (ABO, ISSN 0004-2749 - print and ISSN 1678-2925 - electronic version), the official bimonthly publication of the Brazilian Council of Ophthalmology (CBO), aims to disseminate scientific studies in Ophthalmology, Visual Science and Health public, by promoting research, improvement and updating of professionals related to the field.
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