“Targeting Neuroimmune Pathways in Epilepsy: Advances in Mechanisms and Emerging Therapeutics”

IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Manish Ravikumar, Deenathayalan Uvarajan, Brindha Durairaj
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引用次数: 0

Abstract

The interaction between immune system dysfunction and neuroinflammation is crucial for the development and progression of epilepsy. This study investigates the complex relationships between immune responses and the onset of epileptic seizures and highlights the influence of neuroinflammatory processes on neuronal integrity and seizure frequency. Key factors such as glial cell activation, release of pro-inflammatory cytokines, and disruption of the blood-brain barrier (BBB) are being investigated for their roles in immune-mediated neurological disorders. The review examines novel therapeutic approaches targeting neuroinflammatory pathways. It highlights their potential to reduce seizure onset and development while addressing challenges in translating research into clinical practice. This study aims to elucidate these pathways, address knowledge gaps and explore novel options for epilepsy treatment.

靶向癫痫的神经免疫通路:机制和新兴疗法的进展。
免疫系统功能障碍和神经炎症之间的相互作用对癫痫的发生和发展至关重要。本研究探讨了免疫反应与癫痫发作之间的复杂关系,并强调了神经炎症过程对神经元完整性和癫痫发作频率的影响。神经胶质细胞活化、促炎细胞因子释放和血脑屏障(BBB)破坏等关键因素正在研究它们在免疫介导的神经系统疾病中的作用。本文综述了针对神经炎症途径的新型治疗方法。它强调了它们在减少癫痫发作和发展的潜力,同时解决了将研究转化为临床实践的挑战。本研究旨在阐明这些途径,解决知识空白,探索癫痫治疗的新选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neurochemical Research
Neurochemical Research 医学-神经科学
CiteScore
7.70
自引率
2.30%
发文量
320
审稿时长
6 months
期刊介绍: Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.
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