Gangliosides and cholesterol, two major components of the membrane lipid rafts, as news regulatory partners for Stress Granules assembly.

IF 3.3 3区生物学 Q3 CELL BIOLOGY

Cell Stress & Chaperones Pub Date : 2025-07-19 DOI:10.1016/j.cstres.2025.100093

Anaïs Aulas, Coralie Di Scala

引用次数: 0

Abstract

Stress granules are cytoplasmic inclusions with cyto-protective functions assembling in response to stress. They are now accepted to be part of the pathological mechanism in several diseases, from cancer to neurodegenerative disorders. However, the field is still struggling to find common regulators of their assembly and function. In this study, we describe a mechanism involving lipid rafts (gangliosides and cholesterol),in the regulation of stress granules formation. This study reports that membrane lipid composition is able to regulate the formation of stress granules potentially unraveling several disease mechanisms.

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膜脂筏的两种主要成分神经节苷和胆固醇作为应激颗粒组装的新调控伙伴。

应激颗粒是一种具有细胞保护功能的细胞质内含物，在应激反应中聚集而成。它们现在被认为是从癌症到神经退行性疾病等几种疾病的病理机制的一部分。然而，该领域仍在努力寻找其组装和功能的共同监管机构。在这项研究中，我们描述了一种涉及脂筏（神经节苷脂和胆固醇）的机制，在调节应激颗粒的形成。本研究报道，膜脂组成能够调节应激颗粒的形成，可能揭示几种疾病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress & Chaperones 生物-细胞生物学

CiteScore

7.60

自引率

2.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Stress and Chaperones is an integrative journal that bridges the gap between laboratory model systems and natural populations. The journal captures the eclectic spirit of the cellular stress response field in a single, concentrated source of current information. Major emphasis is placed on the effects of climate change on individual species in the natural environment and their capacity to adapt. This emphasis expands our focus on stress biology and medicine by linking climate change effects to research on cellular stress responses of animals, micro-organisms and plants.