A waste-free packed-bed continuous-flow synthesis of disulfiram with a composite catalyst†

IF 3.1 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Reaction Chemistry & Engineering Pub Date : 2025-04-18 DOI:10.1039/D5RE00028A

Yu-Zhen Xue, Xing-Jian Li, Ze-Run Zhao, Hao-Xing Xu, Shun-Guo Fu, Fang-Xiao Wang and Xiao Wang

引用次数: 0

Abstract

Disulfiram, a star molecule in the rubber, pharmaceutical and agrochemical industries, has been encountering multiple challenges for its conventional synthesis. In this work, a highly sustainable and efficient MoS₂-catalyzed continuous-flow synthesis of TETD has been developed, providing high yield and purity of products upon simple isolation. This process uses O₂ and ethanol as a green oxidant and solvent, without any sacrificing redox agent, rendering it fully atom-economic. The packed-bed filled with MoS₂ and the co-catalyst Ca(OH)₂ is low-leaching and reusable. The structurally similar rubber accelerator tetramethylthiuram disulfide (TMTD) was also synthesized using this method.

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用复合催化剂制备无废填料床连续流法合成双硫仑

双硫醚是橡胶、制药和农化行业的明星分子，其传统合成方法一直面临着诸多挑战。在这项工作中，开发了一种高度可持续和高效的二硫化钼催化的TETD连续流合成方法，在简单的分离中提供了高收率和高纯度的产品。该工艺使用O2和乙醇作为绿色氧化剂和溶剂，不牺牲任何氧化还原剂，使其完全具有原子经济性。以二硫化钼和助催化剂Ca(OH)2填充的填充床具有低浸出和可重复使用的特点。并用该方法合成了结构相似的橡胶促进剂四甲基硫脲二硫化（TMTD）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reaction Chemistry & Engineering Chemistry-Chemistry (miscellaneous)

CiteScore

6.60

自引率

7.70%

发文量

227

期刊介绍： Reaction Chemistry & Engineering is a new journal reporting cutting edge research into all aspects of making molecules for the benefit of fundamental research, applied processes and wider society. From fundamental, molecular-level chemistry to large scale chemical production, Reaction Chemistry & Engineering brings together communities of chemists and chemical engineers working to ensure the crucial role of reaction chemistry in today’s world.