Neurological disorders related to pediatric dengue infection

IF 2.1 4区医学 Q2 CLINICAL NEUROLOGY

Seminars in Pediatric Neurology Pub Date : 2025-07-01 DOI:10.1016/j.spen.2025.101210

Manuel Vides-Rosales , Diego Vides-Tesorero , Jaime Twanow

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引用次数: 0

Abstract

In the last decade, Dengue virus has become a major public health concern, with increasing numbers of infections, hospitalizations, and deaths worldwide. The Aedes mosquito vector’s migration, aided by adaptation to climate change has allowed Dengue virus to spread into temperate regions. The major impact of the disease occurs in regions with limited resources, creating a significant burden for these countries. There is a growing body of information characterizing the neurological disorders related to pediatric Dengue infection. In addition to reviewing Dengue virus structure, disease diagnostic criteria and current WHO guidelines, this article discusses the neuropathogenic mechanisms of infection, and the resultant impact on the central and peripheral nervous systems. Our group has created a framework correlating the presentation of neurologic disorders to Dengue virus phases of infection. There is an urgent need for epidemiological analysis and a systematic approach to catalogue the emerging reports of pediatric neurological disorders related to dengue virus infection. We propose that key regional and professional stakeholders could foster educational advances and improve preventative, diagnostic and therapeutic care of pediatric patients impacted by Dengue virus.

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与小儿登革热感染相关的神经系统疾病

在过去十年中，登革热病毒已成为一个主要的公共卫生问题，全世界感染、住院和死亡人数不断增加。伊蚊媒介的迁移，在适应气候变化的帮助下，使登革热病毒传播到温带地区。该病的主要影响发生在资源有限的区域，给这些国家造成重大负担。越来越多的信息描述了与小儿登革热感染有关的神经系统疾病。除了回顾登革病毒结构、疾病诊断标准和目前的世卫组织指南外，本文还讨论了感染的神经致病机制以及对中枢和周围神经系统的影响。我们的小组创建了一个框架，将神经系统疾病的表现与登革热病毒感染阶段联系起来。目前迫切需要进行流行病学分析，并采用系统方法对与登革热病毒感染有关的儿科神经系统疾病的新报告进行编目。我们建议，关键的区域和专业利益攸关方可以促进教育进步，改善受登革热病毒影响的儿科患者的预防、诊断和治疗护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Pediatric Neurology CLINICAL NEUROLOGY-PEDIATRICS

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

84 days

期刊介绍： Seminars in Pediatric Neurology is a topical journal that focuses on subjects of current importance in the field of pediatric neurology. The journal is devoted to making the status of such topics and the results of new investigations readily available to the practicing physician. Seminars in Pediatric Neurology is of special interest to pediatric neurologists, pediatric neuropathologists, behavioral pediatricians, and neurologists who treat all ages.