Research progress of ASIC family in tumors

IF 3.5 3区 生物学 Q3 CELL BIOLOGY
Xing Wan , Liming Zhou
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引用次数: 0

Abstract

As a proton-gated cation channel, the acid-sensitive ion channels (ASICs) is capable of sensing changes in the extracellular pH value. ASICs are widely distributed and apart from physiological functions, play a role in various diseases related to acidity, such as pain, inflammation, and ischemia. Moreover, studies have shown that ASICs also have an impact on the occurrence, development, invasion, metastasis, and drug resistance of tumors under acidosis conditions. Although the underlying mechanisms of ASIC-mediated processes have not been extensively explored, these studies suggest that ASICs may emerge as novel biomarkers and therapeutic targets, offering new perspectives for the development of alternative cancer therapies. This article reviews the latest progress of ASICs in tumors, summarizes the classic substances that affect their activity, and analyzes the future research directions, providing a basis for them to be potential targets for tumor treatment.

Abstract Image

肿瘤ASIC家族的研究进展
酸敏离子通道(asic)是一种质子门控的阳离子通道,能够感知细胞外pH值的变化。asic分布广泛,除生理功能外,还在疼痛、炎症、缺血等多种与酸性有关的疾病中发挥作用。此外,研究表明,asic对酸中毒条件下肿瘤的发生、发展、侵袭、转移和耐药也有影响。虽然asic介导过程的潜在机制尚未被广泛探索,但这些研究表明asic可能成为新的生物标志物和治疗靶点,为癌症替代疗法的发展提供了新的视角。本文综述了asic在肿瘤中的最新进展,总结了影响其活性的经典物质,并分析了未来的研究方向,为asic成为肿瘤治疗的潜在靶点提供依据。
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来源期刊
Experimental cell research
Experimental cell research 医学-细胞生物学
CiteScore
7.20
自引率
0.00%
发文量
295
审稿时长
30 days
期刊介绍: Our scope includes but is not limited to areas such as: Chromosome biology; Chromatin and epigenetics; DNA repair; Gene regulation; Nuclear import-export; RNA processing; Non-coding RNAs; Organelle biology; The cytoskeleton; Intracellular trafficking; Cell-cell and cell-matrix interactions; Cell motility and migration; Cell proliferation; Cellular differentiation; Signal transduction; Programmed cell death.
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