Effectiveness of rehabilitation treatment for bone metastasis patients without surgical intervention: A propensity score matching analysis

IF 3.5 2区医学 Q2 Medicine

Journal of Bone Oncology Pub Date : 2025-07-19 DOI:10.1016/j.jbo.2025.100703

Ryo Yoshikawa , Yasumitsu Fujii , Ryoga Kashima , Wataru Saho , Risa Harada , Daisuke Makiura , Katsuya Fujiwara , Junichiro Inoue , Yoshiki Takeoka , Ryoko Sawada , Naomasa Fukase , Keisuke Oe , Hitomi Hara , Kenichiro Kakutani , Toshihiro Akisue , Yoshitada Sakai

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引用次数: 0

Abstract

Evidence regarding the effectiveness of rehabilitation treatments in patients with bone metastases remains limited. This study evaluated the implementation and effectiveness of rehabilitation in patients with bone metastases who did not undergo surgery. This retrospective study included 200 patients with nonsurgically treated bone metastases at our institution. The patients were categorized into a rehabilitation group (R group, n = 61) and a non-rehabilitation group (N group, n = 139). Over the course of one month, we compared activities of daily living (ADL), assessed using the Barthel Index (BI), quality of life (QOL), measured using the EuroQoL-5 Dimension (EQ-5D), and demographic and clinical characteristics. Propensity score matching was conducted to minimize selection bias. After matching, 31 patients in each group were included in the analysis. No statistically significant differences were observed in baseline BI and EQ-5D scores between the two groups. In the R group, BI improved significantly from 80 (interquartile range [IQR]: 60–100) to 90 (IQR: 70–100), and EQ-5D improved from 0.444 (IQR: 0.282–0.608) to 0.608 (IQR: 0.533–0.768). In contrast, no improvements were observed in either score in the N group. Chemotherapy was identified as a significant factor associated with improvements in BI (odds ratio 4.03) and EQ-5D (odds ratio 5.29). Rehabilitation may be a valuable treatment option for nonsurgically treated patients with bone metastases, warranting further validation in prospective studies.

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骨转移患者无手术干预的康复治疗效果：倾向评分匹配分析

关于骨转移患者康复治疗有效性的证据仍然有限。本研究评估了未接受手术的骨转移患者康复治疗的实施和效果。本回顾性研究纳入我院200例非手术治疗的骨转移患者。将患者分为康复组（R组，n = 61）和非康复组（n组，n = 139）。在一个月的过程中，我们比较了日常生活活动（ADL），使用Barthel指数（BI）评估，生活质量（QOL），使用EuroQoL-5维度（EQ-5D）测量，以及人口统计学和临床特征。进行倾向评分匹配以尽量减少选择偏差。匹配后，每组31例纳入分析。两组基线BI和EQ-5D评分无统计学差异。在R组，BI从80（四分位间距[IQR]: 60-100）显著改善到90 (IQR: 70-100)， EQ-5D从0.444 （IQR: 0.282-0.608）改善到0.608 （IQR: 0.533-0.768）。相比之下，N组的两项评分均未见改善。化疗被认为是与BI（优势比4.03）和EQ-5D（优势比5.29）改善相关的重要因素。康复治疗对于非手术治疗的骨转移患者可能是一种有价值的治疗选择，需要在前瞻性研究中进一步验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bone Oncology ONCOLOGY-

CiteScore

7.20

自引率

2.90%

发文量

审稿时长

34 days

期刊介绍： The Journal of Bone Oncology is a peer-reviewed international journal aimed at presenting basic, translational and clinical high-quality research related to bone and cancer. As the first journal dedicated to cancer induced bone diseases, JBO welcomes original research articles, review articles, editorials and opinion pieces. Case reports will only be considered in exceptional circumstances and only when accompanied by a comprehensive review of the subject. The areas covered by the journal include: Bone metastases (pathophysiology, epidemiology, diagnostics, clinical features, prevention, treatment) Preclinical models of metastasis Bone microenvironment in cancer (stem cell, bone cell and cancer interactions) Bone targeted therapy (pharmacology, therapeutic targets, drug development, clinical trials, side-effects, outcome research, health economics) Cancer treatment induced bone loss (epidemiology, pathophysiology, prevention and management) Bone imaging (clinical and animal, skeletal interventional radiology) Bone biomarkers (clinical and translational applications) Radiotherapy and radio-isotopes Skeletal complications Bone pain (mechanisms and management) Orthopaedic cancer surgery Primary bone tumours Clinical guidelines Multidisciplinary care Keywords: bisphosphonate, bone, breast cancer, cancer, CTIBL, denosumab, metastasis, myeloma, osteoblast, osteoclast, osteooncology, osteo-oncology, prostate cancer, skeleton, tumour.