Nickel-Catalyzed Direct Enantioselective Alkynylation of Alkynyl Bromide with Secondary Phosphine Oxides

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-21 DOI:10.1021/acs.orglett.5c02339

Yu Tian, Bo-Xin Zhang, Wen-Jing Jin, Xiao-Han Li and Yun-Long Zhao*,

引用次数: 0

Abstract

Developing a transition-metal-catalyzed method for the synthesis of chiral phosphorus-centered alkynyl compounds remains a considerable challenge. Herein, we report an asymmetric coupling reaction involving nickel-catalyzed alkynyl bromides and secondary phosphine oxides, obtaining a series of chiral alkynyl phosphorus compounds with high yields (up to 74%) and excellent stereoselectivity (up to 97% ee). This method features a broad substrate scope and mild reaction conditions.

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镍催化烷基溴与二次膦氧化物的直接对映选择性烷基化反应。

开发一种过渡金属催化的方法来合成手性磷中心炔基化合物仍然是一个相当大的挑战。本文报道了镍催化的炔基溴化物和仲磷氧化物的不对称偶联反应，得到了一系列收率高（高达74%）和立体选择性高（高达97% ee）的手性炔基磷化合物。该方法底物范围广，反应条件温和。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.