Programmable Pulse Generator for Pain Relief Stimulation using Bioresorbable Electrodes.

IEEE Biomedical Circuits and Systems Conference : healthcare technology : [proceedings]. IEEE Biomedical Circuits and Systems Conference Pub Date : 2023-10-01 DOI:10.1109/biocas58349.2023.10389016

Kangni Liu, Anne Gormaley, Kevin Woeppel, Trent Emerick, X Tracy Cui, Rajkumar Kubendran

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Abstract

Neurostimulation therapies are often applied as an alternative method to pharmaceutical treatment for chronic pain relief. This paper demonstrates the design and implementation of a programmable Pulse Generator (PG) for analgesic nerve stimulation with 3 modes of operation: biphasic asymmetric, biphasic capacitor coupled, and monophasic Degradation On Command (DOC). The PG is implemented on 180nm CMOS technology and could generate up to ± 4mA current pulses in steps of 31μA (8-bit resolution) for pulse duration range of 1-256μs and stimulation frequency range of 16Hz-250kHz. During in vitro studies, capacitor-coupled biphasic stimulation provides electrode stability with only 5Ω impedance change for up to 14 million pulses. In the DOC mode, accelerated degradation of a bioresorbable electrode was observed after 24hrs of stimulation, when its impedance increased from about 100Ω to over 0.2MΩ at 500Hz. The compact, tunable and battery-powered pulse generator printed circuit board (PCB) shows promising results to perform in vivo animal studies for up to 30 hours of continuous stimulation with 26.4mW peak power consumption.

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使用生物可吸收电极的可编程脉冲发生器缓解疼痛刺激。

神经刺激疗法通常作为药物治疗的替代方法来缓解慢性疼痛。本文演示了一种可编程脉冲发生器（PG）的设计和实现，该脉冲发生器具有三种工作模式：双相非对称、双相电容耦合和单相退化指令（DOC）。PG采用180nm CMOS技术实现，脉冲持续时间范围为1 ~ 256μs，刺激频率范围为16hz ~ 250khz，可产生±4mA的电流脉冲，步长为31μA（8位分辨率）。在体外研究中，电容耦合双相刺激为高达1400万个脉冲提供了电极稳定性，只有5Ω阻抗变化。在DOC模式下，生物可吸收电极在刺激24h后，其阻抗从约100Ω增加到500Hz时的0.2MΩ以上，降解速度加快。这种紧凑的、可调谐的、电池供电的脉冲发生器印刷电路板（PCB）显示出有希望的结果，可以在动物体内进行长达30小时的连续刺激，峰值功耗为26.4mW。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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IEEE Biomedical Circuits and Systems Conference : healthcare technology : [proceedings]. IEEE Biomedical Circuits and Systems Conference

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