{"title":"Membrane-Bound Guanylyl Cyclases within the Ciliary Compartment.","authors":"Yue He, Junmin Pan","doi":"10.1021/acs.biochem.5c00326","DOIUrl":null,"url":null,"abstract":"<p><p>Most eukaryotic cells employ a specialized sensory organelle─the cilium─that protrudes from the cell surface as a chemo-mechanical antenna. The dysfunction of cilia is associated with a wide range of human diseases collectively termed ciliopathies. Mounting evidence indicates that nonmotile (primary) cilia orchestrate key developmental and homeostatic processes through spatial regulation of multiple signaling pathways, including Hedgehog, Wnt, and PDGF cascades. Intriguingly, an ancient signal transduction system, guanylyl cyclases (GCs)-cyclic GMP (cGMP) module, is almost exclusively found in ciliated organisms, suggesting coevolution of ciliary architecture and cGMP-mediated signal processing. Although most GCs operate in ciliated cells, the specific membrane GCs which are localized in the cilium and their ciliary functions remain incompletely characterized. This review synthesizes current advances in cilium-restricted receptor-type or membrane-bound GCs while systematically elucidating their functional specialization within the ciliary compartment.</p>","PeriodicalId":28,"journal":{"name":"Biochemistry Biochemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry Biochemistry","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1021/acs.biochem.5c00326","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Most eukaryotic cells employ a specialized sensory organelle─the cilium─that protrudes from the cell surface as a chemo-mechanical antenna. The dysfunction of cilia is associated with a wide range of human diseases collectively termed ciliopathies. Mounting evidence indicates that nonmotile (primary) cilia orchestrate key developmental and homeostatic processes through spatial regulation of multiple signaling pathways, including Hedgehog, Wnt, and PDGF cascades. Intriguingly, an ancient signal transduction system, guanylyl cyclases (GCs)-cyclic GMP (cGMP) module, is almost exclusively found in ciliated organisms, suggesting coevolution of ciliary architecture and cGMP-mediated signal processing. Although most GCs operate in ciliated cells, the specific membrane GCs which are localized in the cilium and their ciliary functions remain incompletely characterized. This review synthesizes current advances in cilium-restricted receptor-type or membrane-bound GCs while systematically elucidating their functional specialization within the ciliary compartment.
期刊介绍：
Biochemistry provides an international forum for publishing exceptional, rigorous, high-impact research across all of biological chemistry. This broad scope includes studies on the chemical, physical, mechanistic, and/or structural basis of biological or cell function, and encompasses the fields of chemical biology, synthetic biology, disease biology, cell biology, nucleic acid biology, neuroscience, structural biology, and biophysics. In addition to traditional Research Articles, Biochemistry also publishes Communications, Viewpoints, and Perspectives, as well as From the Bench articles that report new methods of particular interest to the biological chemistry community.
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