Access to SCF3-Substituted Indolizines via a Photocatalytic Late-Stage Functionalization Protocol.

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-21 DOI:10.1021/acs.orglett.5c02079

Kevin Klaus Stefanoni,René Wilhelm

引用次数: 0

Abstract

A mild, scalable, and highly chemoselective photocatalytic method was developed for direct indolizine functionalization with N-((trifluoromethyl)thio)saccharin, yielding high amounts of desired products while tolerating various functional groups. The photoredox catalyst employed offers a straightforward and inexpensive alternative to commercially available catalysts. Additionally, a 3-SCF3 analogue of a histamine H3 receptor antagonist was synthesized with excellent yield, demonstrating the strategy's potential in developing biologically relevant molecules.

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通过光催化后期功能化方案获得scf3取代的吲哚嗪。

本文开发了一种温和、可扩展、高度化学选择性的光催化方法，用于N-（（三氟甲基）硫代）糖精的直接吲哚化，产生大量所需的产物，同时耐受各种官能团。所采用的光氧化还原催化剂提供了一种直接和廉价的替代市售催化剂。此外，合成了一种组胺H3受体拮抗剂的3-SCF3类似物，产量很高，证明了该策略在开发生物相关分子方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.