Assessing the reliability of ChatGPT in cytogenetic reporting and interpretation: implications for clinical use.

IF 1.3 4区生物学 Q4 GENETICS & HEREDITY

Molecular Cytogenetics Pub Date : 2025-07-18 DOI:10.1186/s13039-025-00717-4

Alain Chebly, Lauren Veronese, Edith Chevret

引用次数: 0

Abstract

This study evaluates the accuracy of ChatGPT in generating chromosomal representations (formulas) based on ISCN rules in clinical cytogenetics. While ChatGPT generated correct answers for simple cases, it frequently failed in complex cases. These findings highlight the limitations of current AI tools in accurate clinical cytogenetic reporting, reinforcing the vital role of skilled clinical cytogeneticists for accurate interpretation and reporting.

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评估ChatGPT在细胞遗传学报告和解释中的可靠性：对临床应用的影响。

本研究评估ChatGPT在临床细胞遗传学中基于ISCN规则生成染色体表示（公式）的准确性。虽然ChatGPT在简单的情况下生成正确的答案，但在复杂的情况下却经常失败。这些发现突出了当前人工智能工具在准确的临床细胞遗传学报告方面的局限性，加强了熟练的临床细胞遗传学家在准确解释和报告方面的重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cytogenetics GENETICS & HEREDITY-

CiteScore

2.60

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： Molecular Cytogenetics encompasses all aspects of chromosome biology and the application of molecular cytogenetic techniques in all areas of biology and medicine, including structural and functional organization of the chromosome and nucleus, genome variation, expression and evolution, chromosome abnormalities and genomic variations in medical genetics and tumor genetics. Molecular Cytogenetics primarily defines a large set of the techniques that operate either with the entire genome or with specific targeted DNA sequences. Topical areas include, but are not limited to: -Structural and functional organization of chromosome and nucleus- Genome variation, expression and evolution- Animal and plant molecular cytogenetics and genomics- Chromosome abnormalities and genomic variations in clinical genetics- Applications in preimplantation, pre- and post-natal diagnosis- Applications in the central nervous system, cancer and haematology research- Previously unreported applications of molecular cytogenetic techniques- Development of new techniques or significant enhancements to established techniques. This journal is a source for numerous scientists all over the world, who wish to improve or introduce molecular cytogenetic techniques into their practice.