Repetitive transcranial magnetic stimulation influences cognitive-motor dual-task performance in children with cerebral palsy: a randomized controlled study.

IF 5.2 2区医学 Q1 ENGINEERING, BIOMEDICAL

Journal of NeuroEngineering and Rehabilitation Pub Date : 2025-07-19 DOI:10.1186/s12984-025-01702-z

Jingyi Zhao, Tingting Peng, Liru Liu, Lu He, Jingbo Zhang, Yuan Zhang, Qingfen Hou, Hongyu Zhou, Xubo Yang, Kaishou Xu

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引用次数: 0

Abstract

Background: Children with cerebral palsy (CP) may face challenges when engaging in activities that require simultaneous cognitive and motor efforts. Repetitive transcranial magnetic stimulation (rTMS) has the potential to improve motor and cognitive functions in some populations. However, the effect of rTMS on the performance of cognitive-motor dual-task in children with CP remains unclear.

Objective: To investigate the efficacy and safety of rTMS on the performance of cognitive-motor dual-task in children with CP.

Methods: In this randomized controlled trial, forty-four children with CP (aged 6-12 years) were recruited. They were randomly allocated to receive 3 consecutive sessions of active or sham rTMS applied to the left dorsolateral prefrontal cortex (DLPFC). Participants were asked to perform the Box and Block Test (BBT) and Serial Subtraction Test (SST) separately or simultaneously before and immediately after each rTMS session.

Results: Forty participants completed the study (22 in the active rTMS group). On day 3, significant enhancements were observed in SST scores for the active rTMS group compared to the sham group (single-task:14.4 ± 1.6 vs. 8.89 ± 1.8, p = 0.024; dual-task: 9.36 ± 1.0 vs. 3.89 ± 1.1, p = 0.001). Under the dual-task condition, the active rTMS group displayed a greater improvement in BBT scores than the sham group on day 3 (8.91 ± 1.03 vs. 3.83 ± 1.14, corrected p = 0.003). There were no notable differences between the two groups in the improvement of BBT scores under the single-task condition. No serious adverse events were reported.

Conclusion: The rTMS applied to the left DLPFC is safe and effective in improving the performance of cognitive-motor dual-task in children with CP.

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重复经颅磁刺激对脑瘫儿童认知-运动双任务表现的影响：一项随机对照研究

背景：脑瘫儿童在参与需要同时进行认知和运动努力的活动时可能面临挑战。重复经颅磁刺激（rTMS）在某些人群中具有改善运动和认知功能的潜力。然而，rTMS对脑瘫儿童认知-运动双任务表现的影响尚不清楚。目的：探讨rTMS对脑瘫儿童认知-运动双任务表现的疗效和安全性。方法：随机对照试验44例（6 ~ 12岁）脑瘫儿童。他们被随机分配接受3个连续的活动或假rTMS应用于左背外侧前额叶皮层（DLPFC）。参与者被要求在每次rTMS之前和之后分别或同时进行盒块测试（BBT）和串行减法测试（SST）。结果：40名参与者完成了研究（22名活跃rTMS组）。在第3天，与假手术组相比，活跃rTMS组的SST评分显著提高(单任务：14.4±1.6比8.89±1.8,p = 0.024；双重任务:9.36±1.0和3.89±1.1,p = 0.001)。在双任务条件下，活跃rTMS组在第3天的BBT评分比假组有更大的改善（8.91±1.03比3.83±1.14，校正p = 0.003）。在单任务条件下，两组之间BBT得分的改善无显著差异。无严重不良事件报告。结论：rTMS应用于左DLPFC对改善CP患儿的认知-运动双任务表现安全有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of NeuroEngineering and Rehabilitation 工程技术-工程：生物医学

CiteScore

9.60

自引率

3.90%

发文量

122

审稿时长

24 months

期刊介绍： Journal of NeuroEngineering and Rehabilitation considers manuscripts on all aspects of research that result from cross-fertilization of the fields of neuroscience, biomedical engineering, and physical medicine & rehabilitation.