Regulation of GLI2 by LINC02560 and its role in hepatocellular carcinoma.

Abstract

This article focuses on the regulation of GLI2 by LINC02560 in HCC. Revealing this mechanism provides a new perspective for the morbidity mechanism and treatment strategy of hepatocellular carcinoma.LINC02560, a long non-coding RNA (lncRNA), is upregulated in hepatocellular carcinoma through interaction with GLI2 protein. They jointly regulate key biological processes such as cell proliferation, invasion, migration and apoptosis. It was found that LINC02560 not only directly binds to GLI2 protein, It also plays a regulatory role by affecting the epigenetic modification of GLI2 gene and the interaction with other transcription factors. These mechanisms contribute to the initiation and progression of HCC. In addition, the expression level of LINC02560 is closely related to the therapeutic effect and prognosis of hepatocellular carcinoma. It provides an important basis for the formulation of individualized treatment plan. Therefore, the study of GLI2 regulation by LINC02560 not only deepens our understanding of the mechanism of morbidity in hepatocellular carcinoma, It also provides important clues for finding new therapeutic targets and improving therapeutic effects.