Role of S-palmitoylation in digestive system diseases.

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-07-18 DOI:10.1038/s41420-025-02629-z

Hanqing Li, Qiuxiang Yuan, Shuangshuang Wang, Tao Yu, Xingsi Qi

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引用次数: 0

Abstract

Digestive system diseases, including liver diseases, gastrointestinal cancers, and inflammatory bowel diseases, pose major health challenges worldwide. These conditions are influenced by a range of key metabolic signaling pathways, many of which are regulated by palmitoylation. Palmitoylation is a type of lipid modification catalyzed by DHHC palmitoyl S-acyltransferases (DHHC-PTAs) and depalmitoylases, which play critical roles in modulating protein localization, stability, and signal transduction. Dysregulation of S-palmitoylation is closely associated with numerous diseases, including these of the digestive system, through multiple key processes such as immune responses, lipid metabolism, and cellular signaling. Decades of investigations have driven the development of a large body of inhibitors targeting zDHHCs and depalmitoylases, such as S-(2-acetamidoethyl) 2-bromohexadecanethioate (MY-D-4), Artemisinin and Lomitapide. This review provides a comprehensive summary of the role of palmitoylation in digestive system diseases, discusses its effect on disease mechanisms. By elucidating the regulatory functions of palmitoylation under these conditions, this review aimed to identify new strategies for the diagnosis and treatment of digestive system disorders.

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s -棕榈酰化在消化系统疾病中的作用。

消化系统疾病，包括肝病、胃肠道癌症和炎症性肠病，在世界范围内构成了重大的健康挑战。这些条件受到一系列关键代谢信号通路的影响，其中许多是由棕榈酰化调节的。棕榈酰化是一种由DHHC棕榈酰s -酰基转移酶（DHHC- ptas）和去棕榈酰化酶催化的脂质修饰，在调节蛋白质定位、稳定性和信号转导中起关键作用。s -棕榈酰化的失调通过免疫反应、脂质代谢和细胞信号传导等多个关键过程与包括消化系统疾病在内的许多疾病密切相关。数十年的研究推动了大量针对zdhhc和去棕榈酰化酶的抑制剂的开发，如S-（2-乙酰氨基乙基）2-溴十六烷酸酯（MY-D-4）、青蒿素和洛米他啶。本文综述了棕榈酰化在消化系统疾病中的作用，并讨论了其对疾病机制的影响。通过阐明棕榈酰化在这些条件下的调节功能，本综述旨在为消化系统疾病的诊断和治疗寻找新的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.