From cooperation to conflicts – A complicated relationship between transcription and replication

IF 2.7 3区生物学 Q2 GENETICS & HEREDITY

DNA Repair Pub Date : 2025-07-16 DOI:10.1016/j.dnarep.2025.103872

Syed Shahid Musvi , Tatiana N. Moiseeva

引用次数: 0

Abstract

A tight coordination between transcription and DNA replication is essential to maintain genome stability. Both excessive transcription and upregulated initiation of DNA replication result in transcription replication conflicts and DNA damage. Interestingly, many replication origins are co-localized with transcription start sites, indicating that transcription may play a role in the initiation of DNA replication. In this review we cover various aspects of replication regulation by transcription - from location of replication origins to various steps of replication initiation, replication timing and transcription-replication conflicts.

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从合作到冲突——转录与复制之间的复杂关系

转录和DNA复制之间的紧密协调是维持基因组稳定所必需的。过度转录和DNA复制起始上调都会导致转录复制冲突和DNA损伤。有趣的是，许多复制起点与转录起始位点共定位，这表明转录可能在DNA复制的起始中发挥作用。在这篇综述中，我们涵盖了转录调控复制的各个方面-从复制起始的位置到复制起始的各个步骤，复制时间和转录-复制冲突。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

DNA Repair 生物-毒理学

CiteScore

7.60

自引率

5.30%

发文量

审稿时长

59 days

期刊介绍： DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease. DNA Repair publishes full-length research articles, brief reports on research, and reviews. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports also will be considered for publication.