Residence at high altitude as a risk factor for high probability of pulmonary hypertension in patients with systemic sclerosis: A case–control study

IF 1.3 Q4 RHEUMATOLOGY

Reumatologia Clinica Pub Date : 2025-06-01 DOI:10.1016/j.reuma.2025.501899

Luis Javier Cajas , Julia Recalde Reyes , Javier Alejandro Correa , Wilder Carvajal , Carolina Torres , José S. Cortés

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Abstract

Introduction

This study investigated the association between high-altitude residence (>2500 m above sea level) and the presence of high probability of pulmonary hypertension (PH) in patients with systemic sclerosis (SSc).

Methods

A retrospective case–control study was conducted with 368 patients diagnosed with SSc at the rheumatology outpatient clinic of a university hospital in Bogotá, Colombia. Patients were divided into two groups based on the presence of high probability of PH. Clinical, demographic, and high-altitude residence data were collected and analyzed. A multiple logistic regression model was used to control confounding variables.

Results

Patients residing at high altitudes had a significantly greater risk of presenting high probability of PH than those living at lower altitudes did (odds ratio: 2.0). Other significant factors included the diffuse cutaneous subtype of SSc and the presence of interstitial lung disease.

Discussion

High-altitude residence is a potential risk factor for presenting high probability of PH in SSc patients, warranting closer monitoring and tailored management in these populations. Further studies are warranted to confirm these findings.

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高海拔居住是系统性硬化症患者高概率肺动脉高压的危险因素：一项病例对照研究

本研究探讨了高海拔居住（海拔2500米）与系统性硬化症（SSc）患者高概率肺动脉高压（PH）之间的关系。方法对哥伦比亚波哥大某大学医院风湿病门诊诊断为SSc的368例患者进行回顾性病例对照研究。根据ph存在的高概率将患者分为两组，收集并分析临床、人口统计学和高海拔居住资料。采用多元逻辑回归模型控制混杂变量。结果生活在高海拔地区的患者出现PH高概率的风险显著高于生活在低海拔地区的患者（优势比：2.0）。其他重要因素包括SSc的弥漫性皮肤亚型和间质性肺疾病的存在。高海拔居住是SSc患者出现高概率PH的潜在危险因素，需要在这些人群中进行更密切的监测和量身定制的管理。需要进一步的研究来证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reumatologia Clinica RHEUMATOLOGY-

CiteScore

2.40

自引率

6.70%

发文量

105

审稿时长

54 days

期刊介绍： Una gran revista para cubrir eficazmente las necesidades de conocimientos en una patología de etiología, expresividad clínica y tratamiento tan amplios. Además es La Publicación Oficial de la Sociedad Española de Reumatología y del Colegio Mexicano de Reumatología y está incluida en los más prestigiosos índices de referencia en medicina.