Increased Alkaline Phosphatase Associated with Brown Algae and Mushroom Extract-Containing Supplement Use.

IF 1.2 Q4 GASTROENTEROLOGY & HEPATOLOGY

Canadian liver journal Pub Date : 2025-03-05 eCollection Date: 2025-05-01 DOI:10.3138/canlivj-2025-0005

Himain Perera, Christopher McCudden, Curtis L Cooper

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引用次数: 0

Abstract

Background: Marked alkaline phosphatase (ALP) elevation as a consequence of drug exposure is uncommon. We report a chronic hepatitis B virus (HBV) positive 47-year-old male patient taking a brown algae and mushroom extract-containing supplement (Umi No Shizuku) with ALP levels almost 7 times the upper limit during routine bloodwork. ALP was 991 U/L (normal 50-112 U/L). All other liver studies were within normal range: alanine aminotransferase (ALT) 32 U/L (normal 10-63 U/L), aspartate aminotransferase (AST) 25 U/L (normal 12-41 U/L), gamma-glutamyl transferase (GGT) 22 U/L (normal 11-105 U/L), and total bilirubin 13 µmol/L (normal ≤ 13 µmol/L).

Methods: Serial bloodwork was conducted to assess liver studies and bone disease markers. Imaging was utilized to exclude liver and bone disease.

Results: Bloodwork and imaging all returned values within the normal range. Interrupting the supplement led to rapid normalization of ALP blood levels in the patient.

Conclusions: The supplement was the only variable changed in this case, leading us to suspect that it was responsible for the elevated ALP levels.

查看原文本刊更多论文

增加碱性磷酸酶与褐藻和蘑菇提取物补充剂的使用有关。

背景：药物暴露引起的明显碱性磷酸酶（ALP）升高并不常见。我们报告一例慢性乙型肝炎病毒（HBV）阳性的47岁男性患者，在常规血液检查中ALP水平几乎是上限的7倍，服用含有褐藻和蘑菇提取物的补充剂（Umi No Shizuku）。ALP为991 U/L（正常50 ~ 112 U/L）。所有其他肝脏检查均在正常范围内：丙氨酸转氨酶（ALT） 32 U/L（正常10-63 U/L），天冬氨酸转氨酶（AST） 25 U/L（正常12-41 U/L）， γ -谷氨酰转移酶（GGT） 22 U/L（正常11-105 U/L），总胆红素13µmol/L（正常≤13µmol/L）。方法：进行系列血检，评估肝脏研究和骨骼疾病标志物。影像学检查排除肝脏和骨骼疾病。结果：血检、影像学结果均在正常范围内。中断补充导致患者血ALP水平迅速正常化。结论：补充剂是本病例中唯一改变的变量，这使我们怀疑它是导致ALP水平升高的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Canadian liver journal

CiteScore

1.10

自引率

0.00%

发文量