Molecular drivers in primary brain tumor formation.

Abstract

Gliomas are a common form of intracranial malignancy in adults with poor overall survival and limited treatment strategies. There is significant genetic heterogeneity in this tumor group with a complex network of signaling that leads to rapid infiltrative growth as well as chemo- and radio-resistance. This chapter will delve into the complex processes and molecular alterations that feed into the formation and growth of these primary brain tumors.