{"title":"Evaluating antimicrobial sutures in laparoscopic abdominal surgery - lessons from the NOVOTILAC LAC trial.","authors":"Aali J Sheen","doi":"10.1007/s00423-025-03771-z","DOIUrl":null,"url":null,"abstract":"<p><p>Surgical site infections (SSIs) remain a clinically significant complication in laparoscopic abdominal surgery, particularly in clean-contaminated procedures such as appendectomy and cholecystectomy. This review examines the findings of the NOVOTILAC LAC trial, a multicentre, double-blind, randomised controlled study evaluating the efficacy of chlorhexidine-coated sutures in reducing SSIs. Although the primary endpoint-30-day SSI rate-did not reach statistical significance, secondary outcomes, including post-operative pain, scar satisfaction, and quality of life, offer a broader perspective on patient recovery. The trial's comprehensive design and inclusion of both elective and emergency cases enhance its relevance to real-world surgical practice. While limitations remain due to low baseline SSI rates and statistical power, the study contributes meaningful data to the evolving landscape of antimicrobial suture technology and underscores the need for further targeted research in high-risk populations.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"225"},"PeriodicalIF":1.8000,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271238/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Langenbeck's Archives of Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00423-025-03771-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Surgical site infections (SSIs) remain a clinically significant complication in laparoscopic abdominal surgery, particularly in clean-contaminated procedures such as appendectomy and cholecystectomy. This review examines the findings of the NOVOTILAC LAC trial, a multicentre, double-blind, randomised controlled study evaluating the efficacy of chlorhexidine-coated sutures in reducing SSIs. Although the primary endpoint-30-day SSI rate-did not reach statistical significance, secondary outcomes, including post-operative pain, scar satisfaction, and quality of life, offer a broader perspective on patient recovery. The trial's comprehensive design and inclusion of both elective and emergency cases enhance its relevance to real-world surgical practice. While limitations remain due to low baseline SSI rates and statistical power, the study contributes meaningful data to the evolving landscape of antimicrobial suture technology and underscores the need for further targeted research in high-risk populations.
期刊介绍：
Langenbeck''s Archives of Surgery aims to publish the best results in the field of clinical surgery and basic surgical research. The main focus is on providing the highest level of clinical research and clinically relevant basic research. The journal, published exclusively in English, will provide an international discussion forum for the controlled results of clinical surgery. The majority of published contributions will be original articles reporting on clinical data from general and visceral surgery, while endocrine surgery will also be covered. Papers on basic surgical principles from the fields of traumatology, vascular and thoracic surgery are also welcome. Evidence-based medicine is an important criterion for the acceptance of papers.
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