In-depth review of breast cancer and inflammation pre-and post-treatment strategies with conventional and novel Steroid agents

Abstract

Breast cancer leads to many women's cancer deaths worldwide and inflammation is essential for tumors to develop, advance and spread within the body. High levels of ongoing inflammation within the tumor help cancer cells multiply, encourage blood vessel formation and allow the cancer cells to evade detection by the immune system, so it is a target of choice for many cancer treatments. The relationship between breast cancer and inflammation is explored, stressing how important both early and late stages are, with both traditional and novel steroid options. For many years, corticosteroids and other conventional steroids have been used to help relieve side effects of treatment and boost the well-being of patients. Even so, steroids only working in certain patients and side effects have pushed scientists to discover new type of steroid derivatives that are better and safer. Targeted inflammation control and altered immune response in tumors by these new steroids could make therapy more successful. This review looks at current evidence from different types of studies to determine steroids' role in treating breast cancer-related inflammation. It also reviews options for using steroids together with chemotherapy, radiotherapy and immunotherapy, focusing on achieving the best anti-inflammatory results while keeping the inability to respond to treatment low. The study also looks at potential future progress in developing steroids, personalized medicine and therapies guided by biomarkers that could greatly improve how breast cancer is managed. Knowing how steroids affect tumors as well as inflammation is necessary for creating good treatment plans that improve breast cancer patients' chances of survival and lower their risk of disease recurrence.