Time-restricted feeding attenuates hepatic inflammation and enhances muscular endurance of biliary cirrhotic rats

IF 5.2 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Hui-Chun Huang , Chien-Lin Chang , Shao-Jung Hsu , Ching-Chih Chang , Chiao-Lin Chuang , Jiing-Chyuan Luo , Ming-Chih Hou , Fa-Yauh Lee
{"title":"Time-restricted feeding attenuates hepatic inflammation and enhances muscular endurance of biliary cirrhotic rats","authors":"Hui-Chun Huang ,&nbsp;Chien-Lin Chang ,&nbsp;Shao-Jung Hsu ,&nbsp;Ching-Chih Chang ,&nbsp;Chiao-Lin Chuang ,&nbsp;Jiing-Chyuan Luo ,&nbsp;Ming-Chih Hou ,&nbsp;Fa-Yauh Lee","doi":"10.1016/j.lfs.2025.123856","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><div>Time-restricted feeding (TRF) influences the metabolism of various nutrients. However, the impact of TRF on liver cirrhosis, sarcopenia and hepatic encephalopathy remains unknown. Herein, we evaluate the effects of TRF on common bile duct ligation (BDL)-induced cirrhotic rats.</div></div><div><h3>Materials and methods</h3><div>A 14-day TRF treatment was conducted from the 15th to 28th day post BDL operation. Then the body weight, muscular change, hemodynamics, biochemistry data, hepatic and muscular histology and protein expressions of various molecules were examined in BDL rats. On the other hand, the effects of TRF treatment on the portal-systemic collaterals, motor activities, and muscular strength and endurance were measured.</div></div><div><h3>Key findings</h3><div>TRF treatment significantly decreased body weight without adverse effects in BDL rats. Meanwhile, TRF treatment reduced cardiac index and portal venous flow, attenuated hepatic inflammation and decreased insulin resistance, reduced oxidized low-density lipoprotein and decreased intrahepatic fat accumulation. The circumference of gastrocnemius muscle did not change despite a significant body weight reduction after TRF. Furthermore, rats' endurance of exercise enhanced after TRF. A 14-day TRF treatment neither ameliorated liver fibrosis nor improved motor activities of BDL rats. In addition, the severity of portal-systemic shunts was not influenced by TRF.</div></div><div><h3>Significance</h3><div>In BDL-induced cirrhotic rats, a 14-day TRF treatment alters hemodynamics, attenuates hepatic inflammation and improves metabolic derangement. Additionally, TRF treatment increases muscular endurance without influencing the circumference of gastrocnemius muscle. However, TRF treatment does not affect liver fibrosis and hepatic encephalopathy.</div></div>","PeriodicalId":18122,"journal":{"name":"Life sciences","volume":"379 ","pages":"Article 123856"},"PeriodicalIF":5.2000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Life sciences","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0024320525004916","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0

Abstract

Aims

Time-restricted feeding (TRF) influences the metabolism of various nutrients. However, the impact of TRF on liver cirrhosis, sarcopenia and hepatic encephalopathy remains unknown. Herein, we evaluate the effects of TRF on common bile duct ligation (BDL)-induced cirrhotic rats.

Materials and methods

A 14-day TRF treatment was conducted from the 15th to 28th day post BDL operation. Then the body weight, muscular change, hemodynamics, biochemistry data, hepatic and muscular histology and protein expressions of various molecules were examined in BDL rats. On the other hand, the effects of TRF treatment on the portal-systemic collaterals, motor activities, and muscular strength and endurance were measured.

Key findings

TRF treatment significantly decreased body weight without adverse effects in BDL rats. Meanwhile, TRF treatment reduced cardiac index and portal venous flow, attenuated hepatic inflammation and decreased insulin resistance, reduced oxidized low-density lipoprotein and decreased intrahepatic fat accumulation. The circumference of gastrocnemius muscle did not change despite a significant body weight reduction after TRF. Furthermore, rats' endurance of exercise enhanced after TRF. A 14-day TRF treatment neither ameliorated liver fibrosis nor improved motor activities of BDL rats. In addition, the severity of portal-systemic shunts was not influenced by TRF.

Significance

In BDL-induced cirrhotic rats, a 14-day TRF treatment alters hemodynamics, attenuates hepatic inflammation and improves metabolic derangement. Additionally, TRF treatment increases muscular endurance without influencing the circumference of gastrocnemius muscle. However, TRF treatment does not affect liver fibrosis and hepatic encephalopathy.
限时喂养可减轻胆汁性肝硬化大鼠肝脏炎症,增强其肌肉耐力。
目的:限时饲喂影响动物体内各种营养物质的代谢。然而,TRF对肝硬化、肌肉减少症和肝性脑病的影响尚不清楚。在此,我们评估了TRF对胆总管结扎(BDL)诱导的肝硬化大鼠的影响。材料与方法:BDL术后15 ~ 28天进行14天TRF治疗。然后观察BDL大鼠的体重、肌肉变化、血流动力学、生化指标、肝脏和肌肉组织学及各分子蛋白表达情况。另一方面,测量了TRF治疗对门静脉系统络、运动活动、肌肉力量和耐力的影响。主要发现:TRF治疗显著降低BDL大鼠体重,无不良反应。同时,TRF治疗可降低心脏指数和门静脉流量,减轻肝脏炎症,降低胰岛素抵抗,降低氧化低密度脂蛋白,减少肝内脂肪堆积。腓肠肌的周长没有改变,尽管在TRF后体重明显减轻。此外,TRF后大鼠的运动耐力增强。14天的TRF治疗既没有改善肝纤维化,也没有改善BDL大鼠的运动活动。此外,门静脉-系统分流的严重程度不受TRF的影响。意义:在bdl诱导的肝硬化大鼠中,14天的TRF治疗改变了血流动力学,减轻了肝脏炎症,改善了代谢紊乱。此外,TRF治疗在不影响腓肠肌周长的情况下增加肌肉耐力。然而,TRF治疗不影响肝纤维化和肝性脑病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Life sciences
Life sciences 医学-药学
CiteScore
12.20
自引率
1.60%
发文量
841
审稿时长
6 months
期刊介绍: Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信