Narrative Review of Perioperative Glucagon-like Peptide-1 (GLP-1) Agonists in Spine Surgery.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

Clinical Spine Surgery Pub Date : 2025-07-17 DOI:10.1097/BSD.0000000000001888

James W Connelly, Rajkishen Narayanan, Teeto Ezeonu, Parth Kothari, Nicholas Spina, William Ryan Spiker, Brandon Lawrence, Darrel S Brodke, Gregory D Schroeder, Brian A Karamian

引用次数: 0

Abstract

Spine surgeons are increasingly likely to encounter patients taking glucagon-like peptide-1 (GLP-1) receptor agonists for glycemic control and/or weight loss. GLP-1 receptor agonists present an attractive option for helping patients meet hemoglobin A1C and body mass index goals before elective surgeries and have already been implemented for these purposes. It is imperative for spine surgeons to understand the potential risks and benefits of these drugs during the perioperative period and their influence on patient outcomes. This review provides an overview of the history of GLP-1 receptor agonists, their mechanism of action and efficacy as a diabetic and weight loss treatment, as well as the clinical relevance to the field of spine surgery. Further studies are required to truly understand the impact of these medications on spine surgery and in the management of these patients in the perioperative period.

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脊柱外科围手术期胰高血糖素样肽-1 （GLP-1）激动剂的叙述综述。

脊柱外科医生越来越多地遇到服用胰高血糖素样肽-1 （GLP-1）受体激动剂来控制血糖和/或减肥的患者。GLP-1受体激动剂提供了一个有吸引力的选择，帮助患者在选择性手术前达到血红蛋白A1C和体重指数目标，并已为此目的实施。脊柱外科医生必须了解这些药物在围手术期的潜在风险和益处以及它们对患者预后的影响。本文综述了GLP-1受体激动剂的历史、作用机制和作为糖尿病和减肥治疗的疗效，以及与脊柱外科领域的临床相关性。需要进一步的研究来真正了解这些药物对脊柱手术和围手术期患者管理的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Spine Surgery Medicine-Surgery

CiteScore

3.00

自引率

5.30%

发文量

236

期刊介绍： Clinical Spine Surgery is the ideal journal for the busy practicing spine surgeon or trainee, as it is the only journal necessary to keep up to date with new clinical research and surgical techniques. Readers get to watch leaders in the field debate controversial topics in a new controversies section, and gain access to evidence-based reviews of important pathologies in the systematic reviews section. The journal features a surgical technique complete with a video, and a tips and tricks section that allows surgeons to review the important steps prior to a complex procedure. Clinical Spine Surgery provides readers with primary research studies, specifically level 1, 2 and 3 studies, ensuring that articles that may actually change a surgeon’s practice will be read and published. Each issue includes a brief article that will help a surgeon better understand the business of healthcare, as well as an article that will help a surgeon understand how to interpret increasingly complex research methodology. Clinical Spine Surgery is your single source for up-to-date, evidence-based recommendations for spine care.