Is There Any Relationship Between Idiopathic Scoliosis and Pineal Gland, Pituitary Gland, and Brain Ventricles?

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

Clinical Spine Surgery Pub Date : 2025-07-17 DOI:10.1097/BSD.0000000000001886

Fatma Yasemin Öksüzler, Mahmut Öksüzler, Sema Polat

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引用次数: 0

Abstract

Study design: Retrospective cohort.

Objective: This paper aims to contribute to the determination of the possible factors that may be associated with idiopathic scoliosis (IS) by assessing the dimensions in the pineal and pituitary gland volumes, and brain ventricle morphometry.

Summary of background data: The role of hormones in growth and development is known. Growth hormones and melatonin play a role in bone metabolism. Some studies have shown that hormones that play roles in growth and development and the glands that secrete these hormones may affect the formation of scoliosis.

Methods: A total of 46 subjects with scoliosis and 52 healthy subjects aged between 18 and 46 years were included in the study. Magnetic resonance imaging was used to measure pineal and pituitary gland volumes and brain ventricles. Also, the Cobb angle was evaluated using X-rays to determine the severity of scoliosis.

Results: The average Cobb angle in the IS group was 33.02±17.02 degrees. The mean volumes of the pineal and pituitary glands were 41.53±19.25 mm3, 215.15±82.39 mm3 in IS, and 57.75±31.04 mm3 and 284.90±96.90 mm3 in healthy groups, respectively (P<0.05). Frontal horn widths, fourth ventricle anteroposterior, and transverse diameters were lower in the IS group than in healthy subjects. There was a significant difference in 3 parameters, including the fourth ventricle anteroposterior, transverse diameter, and third ventricle width (P<0.05).

Conclusion: The differences in the dimensions of pineal, and pituitary glands may be an underlying cause of scoliosis or support a link with scoliosis. Although the values of the brain ventricles differed in both groups, more studies are needed to determine the relationship between the brain ventricles and scoliosis. Gaining insight into neuroendocrine influences on spine development or a comprehensive understanding of how these factors affect the risk and progression of scoliosis is of clinical importance, as it may lead to innovative preventive strategies.

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特发性脊柱侧凸与松果体、脑垂体和脑室有关系吗？

研究设计：回顾性队列。目的：本文旨在通过评估松果体、脑垂体体积的尺寸以及脑室形态学来确定可能与特发性脊柱侧凸（IS）相关的因素。背景资料概述：激素在生长发育中的作用是已知的。生长激素和褪黑激素在骨代谢中起作用。一些研究表明，在生长发育中起作用的激素和分泌这些激素的腺体可能影响脊柱侧凸的形成。方法：选取18 ~ 46岁的脊柱侧凸患者46例，健康人群52例。磁共振成像测量松果体、脑垂体体积和脑室。此外，用x射线评估Cobb角以确定脊柱侧凸的严重程度。结果：IS组平均Cobb角为33.02±17.02度。IS组松果体和垂体的平均体积分别为41.53±19.25 mm3、215.15±82.39 mm3，健康组分别为57.75±31.04 mm3和284.90±96.90 mm3。结论：松果体和垂体的体积差异可能是脊柱侧凸的潜在原因或与脊柱侧凸有关。虽然脑室的数值在两组中有所不同，但需要更多的研究来确定脑室和脊柱侧凸之间的关系。深入了解神经内分泌对脊柱发育的影响或全面了解这些因素如何影响脊柱侧凸的风险和进展具有临床重要性，因为它可能导致创新的预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Spine Surgery Medicine-Surgery

CiteScore

3.00

自引率

5.30%

发文量

236

期刊介绍： Clinical Spine Surgery is the ideal journal for the busy practicing spine surgeon or trainee, as it is the only journal necessary to keep up to date with new clinical research and surgical techniques. Readers get to watch leaders in the field debate controversial topics in a new controversies section, and gain access to evidence-based reviews of important pathologies in the systematic reviews section. The journal features a surgical technique complete with a video, and a tips and tricks section that allows surgeons to review the important steps prior to a complex procedure. Clinical Spine Surgery provides readers with primary research studies, specifically level 1, 2 and 3 studies, ensuring that articles that may actually change a surgeon’s practice will be read and published. Each issue includes a brief article that will help a surgeon better understand the business of healthcare, as well as an article that will help a surgeon understand how to interpret increasingly complex research methodology. Clinical Spine Surgery is your single source for up-to-date, evidence-based recommendations for spine care.