Roadmap to Challenges in Limited Cellularity Specimens from Pancreatic Neuroendocrine Neoplasms: Diagnostic Tools for the Most Appropriate Management of Limited Material.

IF 11.3 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Endocrine Pathology Pub Date : 2025-07-16 DOI:10.1007/s12022-025-09870-3

Stefano La Rosa, Roberta Maragliano, Deborah Marchiori

{"title":"Roadmap to Challenges in Limited Cellularity Specimens from Pancreatic Neuroendocrine Neoplasms: Diagnostic Tools for the Most Appropriate Management of Limited Material.","authors":"Stefano La Rosa, Roberta Maragliano, Deborah Marchiori","doi":"10.1007/s12022-025-09870-3","DOIUrl":null,"url":null,"abstract":"<p><p>Fine needle aspiration (FNA) and fine needle biopsy (FNB) procedures are increasingly employed in the diagnostic work-up of pancreatic masses. These procedures represent a challenge for pathologists who have to adapt to handling specimens of limited cellularity. In several cases, FNA and FNB specimens are the only available material, as many pancreatic neoplasms are surgically unresectable at the time of the initial diagnosis. In the present review paper, the diagnosis of pancreatic neuroendocrine neoplasms in limited cellularity specimens is presented using a morphology-based approach. The aim is to provide a practical guide for pathologists to select the most appropriate ancillary techniques to be used for the diagnostic work-up, while conserving precious material. The integration of morphology, immunohistochemistry, and molecular biology will be discussed to provide the reader with practical tools to solve the main differential diagnostic problems encountered in routine practice when working with cytological samples or small biopsies.</p>","PeriodicalId":55167,"journal":{"name":"Endocrine Pathology","volume":"36 1","pages":"25"},"PeriodicalIF":11.3000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12022-025-09870-3","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Fine needle aspiration (FNA) and fine needle biopsy (FNB) procedures are increasingly employed in the diagnostic work-up of pancreatic masses. These procedures represent a challenge for pathologists who have to adapt to handling specimens of limited cellularity. In several cases, FNA and FNB specimens are the only available material, as many pancreatic neoplasms are surgically unresectable at the time of the initial diagnosis. In the present review paper, the diagnosis of pancreatic neuroendocrine neoplasms in limited cellularity specimens is presented using a morphology-based approach. The aim is to provide a practical guide for pathologists to select the most appropriate ancillary techniques to be used for the diagnostic work-up, while conserving precious material. The integration of morphology, immunohistochemistry, and molecular biology will be discussed to provide the reader with practical tools to solve the main differential diagnostic problems encountered in routine practice when working with cytological samples or small biopsies.

查看原文本刊更多论文

胰腺神经内分泌肿瘤有限细胞标本的挑战路线图：有限材料最适当管理的诊断工具。

细针穿刺（FNA）和细针活检（FNB）程序越来越多地用于胰腺肿块的诊断工作。这些程序代表了病理学家的挑战，他们必须适应处理有限细胞的标本。在一些病例中，FNA和FNB标本是唯一可用的材料，因为许多胰腺肿瘤在最初诊断时无法手术切除。在目前的审查文件，胰腺神经内分泌肿瘤的诊断在有限的细胞标本提出了使用形态学为基础的方法。目的是为病理学家提供一个实用的指导，选择最合适的辅助技术用于诊断工作，同时保存宝贵的材料。将讨论形态学、免疫组织化学和分子生物学的整合，为读者提供实用的工具，以解决日常实践中遇到的主要鉴别诊断问题，当处理细胞学样本或小活检时。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Endocrine Pathology 医学-病理学

CiteScore

12.30

自引率

20.50%

发文量

审稿时长

>12 weeks

期刊介绍： Endocrine Pathology publishes original articles on clinical and basic aspects of endocrine disorders. Work with animals or in vitro techniques is acceptable if it is relevant to human normal or abnormal endocrinology. Manuscripts will be considered for publication in the form of original articles, case reports, clinical case presentations, reviews, and descriptions of techniques. Submission of a paper implies that it reports unpublished work, except in abstract form, and is not being submitted simultaneously to another publication. Accepted manuscripts become the sole property of Endocrine Pathology and may not be published elsewhere without written consent from the publisher. All articles are subject to review by experienced referees. The Editors and Editorial Board judge manuscripts suitable for publication, and decisions by the Editors are final.