What's new in medical renal pathology 2025: Updates on podocytopathy and immunofluorescence staining in medical kidney.

IF 3 Q3 PATHOLOGY

Journal of Pathology and Translational Medicine Pub Date : 2025-07-01 Epub Date: 2025-07-10 DOI:10.4132/jptm.2025.06.19

Astrid Weins, Ibrahim Batal, Paola Romagnani, Geetika Singh, Rahul Raj, Nicole Andeen, Jonathan Zuckerman, Martina Uzzo, Mariam Priya Alexander, Anjali Satoskar

引用次数: 0

Abstract

Diffuse podocytopathy, including minimal change disease and primary focal segmental glomerulosclerosis, is a common cause of nephrotic syndrome in adults and children. It is increasingly recognized to be autoimmune-mediated associated with anti-nephrin and other emerging anti-slit diaphragm antibodies, and can recur in the kidney allograft. Immunofluorescence is routinely used in evaluation of kidney biopsies, and updates include those on fibrillar diseases, monoclonal staining, lupus-like staining, and use of antibody KM55 in IgA-dominant glomerulonephritis.

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医学肾脏病理学2025最新进展：医学肾脏足细胞病和免疫荧光染色的最新进展。

弥漫性足细胞病，包括微小改变病和原发性局灶节段性肾小球硬化，是成人和儿童肾病综合征的常见病因。它被越来越多地认为是自身免疫介导的，与抗肾素和其他新出现的抗狭缝隔膜抗体相关，并且可以在同种异体肾移植中复发。免疫荧光常规用于评估肾活检，更新包括纤原性疾病、单克隆染色、狼疮样染色和抗体KM55在iga显性肾小球肾炎中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pathology and Translational Medicine PATHOLOGY-

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

14 weeks

期刊介绍： The Journal of Pathology and Translational Medicine is an open venue for the rapid publication of major achievements in various fields of pathology, cytopathology, and biomedical and translational research. The Journal aims to share new insights into the molecular and cellular mechanisms of human diseases and to report major advances in both experimental and clinical medicine, with a particular emphasis on translational research. The investigations of human cells and tissues using high-dimensional biology techniques such as genomics and proteomics will be given a high priority. Articles on stem cell biology are also welcome. The categories of manuscript include original articles, review and perspective articles, case studies, brief case reports, and letters to the editor.