Clinical Outcome of Febrile Neutropenia and Associated Factors Among Adult Patients with Cancer Treated at Ethiopian Oncology Centers: A Retrospective Observational Study.
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引用次数: 0
Abstract
Introduction: Febrile neutropenia (FN) is a major cause of dose-limiting complications in cancer treatment that predisposes patients to serious infections. Despite advancements in therapies, including empirical and definitive antibiotics, FN remains a major morbidity and mortality issue among patients with cancer undergoing cancer treatment. Little is known about the 30-day all-cause mortality rates from FN in Ethiopia, particularly in the Northwest Ethiopia oncology centers.
Methods: This retrospective cross-sectional study was conducted via chart review without direct patient contact at two Northwest Ethiopia oncology centers. Adult patients diagnosed with cancer who developed FN and were treated at the two oncology centers between July 2017 and July 2021 were included in the study. Multivariable logistic regression was used to identify factors associated with 30-day all-cause mortality, with statistical significance determined at P < 0.05 and a 95% confidence interval (CI).
Results: A total of 405 patients with FN were included in the final analysis. The overall 30-day all-cause mortality was 20.7%. Age > 60 years [adjusted odds ratio (AOR) = 3.1, 95% CI (1.6-5.9), P = 0.009], low Multinational Association for Supportive Care in Cancer (MASCC) score [AOR = 4.8, 95% CI (2.5-9.1), P = 0.0001], hypoalbuminemia [AOR = 2.8, 95% CI (1.4-5.8), P = 0.026], lymphopenia [AOR = 4.9, 95% CI (2.9-6.5), P = 0.001], and elevated gamma-glutamyl transferase (GGT) [AOR = 3.5, 95% CI (1.5-4.7), P = 0.009] were significantly associated with 30-day all-cause mortality.
Conclusion: The 30-day all-cause mortality rate was high among patients with FN. Old age, low MASCC score, hypoalbuminemia, lymphopenia, and elevated GGT levels were found to be significantly associated with 30-day all-cause mortality. Healthcare providers should consider these factors in order to manage and mitigate the risks associated with the 30-day all-cause mortality. Further prospective studies are warranted to confirm our results and identify therapeutic strategies that can improve survival.
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Aims and Scope
Oncology and Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality pre-clinical, clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged.
The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Oncology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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