Diagnostic Value of Platelet Count, Alanine Aminotransferase, and Fibrinogen in Differentiating Incomplete Kawasaki Disease from Sepsis.

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

SHOCK Pub Date : 2025-06-05 DOI:10.1097/SHK.0000000000002647

Lu Yu, Wen-Hua Yan, Jie-Ru Chen

{"title":"Diagnostic Value of Platelet Count, Alanine Aminotransferase, and Fibrinogen in Differentiating Incomplete Kawasaki Disease from Sepsis.","authors":"Lu Yu, Wen-Hua Yan, Jie-Ru Chen","doi":"10.1097/SHK.0000000000002647","DOIUrl":null,"url":null,"abstract":"Objective: The aim of this study is to compare laboratory parameters between incomplete Kawasaki disease (IKD) and sepsis, and to evaluate the predictive value of common laboratory parameters in distinguishing IKD from sepsis.Methods: A retrospective analysis was conducted on medical records of patients diagnosed with Kawasaki disease (KD) or sepsis between January 2021 and December 2023. A total of 207 cases of IKD and 315 cases of sepsis were included in this study. Clinical data were analyzed to identify intergroup differences.Results: Significant intergroup differences (p < 0.05) were observed in blood platelet (PLT) count, procalcitonin, aspartate aminotransferase, alanine aminotransferase (ALT), urea nitrogen, creatinine, C-reactive protein, fibrinogen (Fib), and D-dimer levels. Markers with statistically significant variations relevant to the diagnosis of IKD were identified using binary logistic regression analysis. Receiver operating characteristic curve analysis demonstrated areas under the curve of 0.771 for PLT, 0.800 for ALT, and 0.755 for Fib. A combined assessment of these markers resulted in improved sensitivity and specificity.Conclusion: PLT, ALT, and Fib can serve as laboratory markers for distinguishing IKD from sepsis and offer diagnostic reference value. Their combined assessment may improve the predictive accuracy for IKD.","PeriodicalId":21667,"journal":{"name":"SHOCK","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"SHOCK","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/SHK.0000000000002647","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CRITICAL CARE MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: The aim of this study is to compare laboratory parameters between incomplete Kawasaki disease (IKD) and sepsis, and to evaluate the predictive value of common laboratory parameters in distinguishing IKD from sepsis.

Methods: A retrospective analysis was conducted on medical records of patients diagnosed with Kawasaki disease (KD) or sepsis between January 2021 and December 2023. A total of 207 cases of IKD and 315 cases of sepsis were included in this study. Clinical data were analyzed to identify intergroup differences.

Results: Significant intergroup differences (p < 0.05) were observed in blood platelet (PLT) count, procalcitonin, aspartate aminotransferase, alanine aminotransferase (ALT), urea nitrogen, creatinine, C-reactive protein, fibrinogen (Fib), and D-dimer levels. Markers with statistically significant variations relevant to the diagnosis of IKD were identified using binary logistic regression analysis. Receiver operating characteristic curve analysis demonstrated areas under the curve of 0.771 for PLT, 0.800 for ALT, and 0.755 for Fib. A combined assessment of these markers resulted in improved sensitivity and specificity.

Conclusion: PLT, ALT, and Fib can serve as laboratory markers for distinguishing IKD from sepsis and offer diagnostic reference value. Their combined assessment may improve the predictive accuracy for IKD.

查看原文本刊更多论文

血小板计数、丙氨酸转氨酶和纤维蛋白原对不完全性川崎病与败血症的诊断价值。

目的：比较不完全川崎病（IKD）与脓毒症的实验室参数，探讨常见的实验室参数对区分不完全川崎病与脓毒症的预测价值。方法：回顾性分析2021年1月至2023年12月诊断为川崎病（KD）或败血症患者的病历。本研究共纳入IKD 207例，脓毒症315例。分析临床资料以确定组间差异。结果：各组患者血小板（PLT）、降钙素原、天冬氨酸转氨酶、丙氨酸转氨酶（ALT）、尿素氮、肌酐、c反应蛋白、纤维蛋白原（Fib）、d -二聚体水平差异均有统计学意义（p < 0.05）。使用二元逻辑回归分析确定与IKD诊断相关的具有统计学显著差异的标志物。受试者工作特征曲线分析显示，PLT曲线下面积为0.771，ALT为0.800，Fib为0.755。对这些标志物的综合评估提高了敏感性和特异性。结论：PLT、ALT、Fib可作为区分IKD与败血症的实验室指标，具有诊断参考价值。他们的综合评估可以提高IKD的预测准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

SHOCK 医学-外科

CiteScore

6.20

自引率

3.20%

发文量

199

审稿时长

1 months

期刊介绍： SHOCK®: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches includes studies of novel therapeutic approaches, such as immunomodulation, gene therapy, nutrition, and others. The mission of the Journal is to foster and promote multidisciplinary studies, both experimental and clinical in nature, that critically examine the etiology, mechanisms and novel therapeutics of shock-related pathophysiological conditions. Its purpose is to excel as a vehicle for timely publication in the areas of basic and clinical studies of shock, trauma, sepsis, inflammation, ischemia, and related pathobiological states, with particular emphasis on the biologic mechanisms that determine the response to such injury. Making such information available will ultimately facilitate improved care of the traumatized or septic individual.