Robust Bayesian Inference in the Multilevel Zero-Inflated Generalized Poisson Model.

IF 1.8 4区 医学 Q3 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Mekuanint Simeneh Workie, Xu Yi
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引用次数: 0

Abstract

Outliers, over-dispersion, and zero inflation are issues with count data. Traditional models like Poisson and negative binomial often fail to account for these issues, leading to biased estimates and poor model fit. These frameworks are extended by the Zero-Inflated Generalized Poisson (ZIGP) model, which takes into consideration not only zero inflation but also over-dispersion or under-dispersion. However, in the presence of outliers and hierarchical data structures. This study develops a robust Bayesian inference framework for the multilevel ZIGP model. Standard Bayesian methods often lack robustness under model misspecification and in the presence of outlier data. The framework uses a Robust expectation solution (RES) algorithm and generalized Bayesian inference (GBI) for robust estimation against outliers. These approaches improve estimation accuracy using robust loss functions and scaling parameters to minimize the influence of outliers. Simulation studies confirm that the Robust Expectation Solution (RES) algorithm significantly outperformed the Expectation-Maximization (EM) algorithm in reducing bias and mean squared error (MSE), especially in the presence of outliers. Regular Bayesian and EM algorithms were more sensitive to outliers, leading to potential bias and instability in parameter estimates. Our robust Bayesian framework, specifically the Generalized Bayesian Inference (GBI), demonstrated improved robustness and stability under model misspecification and outlier contamination. The main results show that tuning quantiles and optimizing scaling parameters improved parameter calibration and reduced bias and mean square error (MSE). We applied the framework to neonatal mortality data, identifying key risk factors such as maternal education, wealth status, rural residence, and age at first birth.

多水平零膨胀广义泊松模型的鲁棒贝叶斯推理。
异常值、过度分散和零膨胀是计数数据的问题。像泊松和负二项等传统模型往往不能解释这些问题,导致有偏见的估计和较差的模型拟合。这些框架被零膨胀广义泊松(ZIGP)模型扩展,该模型不仅考虑了零膨胀,而且考虑了过色散或欠色散。然而,在存在异常值和分层数据结构的情况下。本研究为多级ZIGP模型开发了一个鲁棒的贝叶斯推理框架。标准贝叶斯方法在模型不规范和存在离群数据的情况下往往缺乏鲁棒性。该框架使用鲁棒期望解(RES)算法和广义贝叶斯推理(GBI)对异常值进行鲁棒估计。这些方法使用鲁棒损失函数和尺度参数来提高估计精度,以最小化异常值的影响。仿真研究证实,鲁棒期望解决(RES)算法在减少偏差和均方误差(MSE)方面明显优于期望最大化(EM)算法,特别是在存在异常值的情况下。常规贝叶斯和EM算法对异常值更敏感,导致参数估计的潜在偏差和不稳定性。我们的鲁棒贝叶斯框架,特别是广义贝叶斯推理(GBI),在模型错误规范和离群值污染下表现出更好的鲁棒性和稳定性。主要结果表明,分位数的调整和尺度参数的优化改善了参数校准,降低了偏差和均方误差(MSE)。我们将该框架应用于新生儿死亡率数据,确定了关键的风险因素,如产妇教育程度、财富状况、农村居住和首次生育年龄。
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来源期刊
Statistics in Medicine
Statistics in Medicine 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.40
自引率
10.00%
发文量
334
审稿时长
2-4 weeks
期刊介绍: The journal aims to influence practice in medicine and its associated sciences through the publication of papers on statistical and other quantitative methods. Papers will explain new methods and demonstrate their application, preferably through a substantive, real, motivating example or a comprehensive evaluation based on an illustrative example. Alternatively, papers will report on case-studies where creative use or technical generalizations of established methodology is directed towards a substantive application. Reviews of, and tutorials on, general topics relevant to the application of statistics to medicine will also be published. The main criteria for publication are appropriateness of the statistical methods to a particular medical problem and clarity of exposition. Papers with primarily mathematical content will be excluded. The journal aims to enhance communication between statisticians, clinicians and medical researchers.
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