Unlocking cardiac health: exploring the role of class I HDACs in cardiovascular diseases.

IF 3.5 2区生物学 Q3 CELL BIOLOGY

Molecular and Cellular Biochemistry Pub Date : 2025-07-14 DOI:10.1007/s11010-025-05353-5

Padmini Pai, Rachel Savio D'Mello, Ojasvi Mangesh Brahme, Yoga Varshitha Gogineni, Manasa Gangadhar Shetty, Babitha Kampa Sundara

{"title":"Unlocking cardiac health: exploring the role of class I HDACs in cardiovascular diseases.","authors":"Padmini Pai, Rachel Savio D'Mello, Ojasvi Mangesh Brahme, Yoga Varshitha Gogineni, Manasa Gangadhar Shetty, Babitha Kampa Sundara","doi":"10.1007/s11010-025-05353-5","DOIUrl":null,"url":null,"abstract":"<p><p>Translation modifications, particularly those involving histone deacetylases (HDACs), are crucial for regulating gene expression and have significant implications for cardiovascular disease (CVD). The association between HDACs and CVD has garnered significant research interest due to the pivotal role of HDACs in gene expression regulation and cellular function. Aberrant HDAC activity has been implicated in various pathological processes underlying CVD, including inflammation, endothelial dysfunction, hypertrophy, fibrosis, and atherosclerosis. This review explores the molecular mechanisms by which different HDAC isoforms influence cardiovascular pathology, highlighting evidence from preclinical and clinical studies. Emerging data suggest that HDAC inhibitors could offer therapeutic potential by modulating these processes and improving cardiovascular health. However, the precise isoform-specific roles and therapeutic window for HDAC inhibition in CVD remain to be elucidated. Furthermore, research is essential to identify the crucial and complex relationship between HDACs and cardiovascular health, which could pave the way for novel, targeted interventions for the treatment of CVD.</p>","PeriodicalId":18724,"journal":{"name":"Molecular and Cellular Biochemistry","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular and Cellular Biochemistry","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s11010-025-05353-5","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Translation modifications, particularly those involving histone deacetylases (HDACs), are crucial for regulating gene expression and have significant implications for cardiovascular disease (CVD). The association between HDACs and CVD has garnered significant research interest due to the pivotal role of HDACs in gene expression regulation and cellular function. Aberrant HDAC activity has been implicated in various pathological processes underlying CVD, including inflammation, endothelial dysfunction, hypertrophy, fibrosis, and atherosclerosis. This review explores the molecular mechanisms by which different HDAC isoforms influence cardiovascular pathology, highlighting evidence from preclinical and clinical studies. Emerging data suggest that HDAC inhibitors could offer therapeutic potential by modulating these processes and improving cardiovascular health. However, the precise isoform-specific roles and therapeutic window for HDAC inhibition in CVD remain to be elucidated. Furthermore, research is essential to identify the crucial and complex relationship between HDACs and cardiovascular health, which could pave the way for novel, targeted interventions for the treatment of CVD.

查看原文本刊更多论文

解锁心脏健康：探索I类hdac在心血管疾病中的作用。

翻译修饰，特别是涉及组蛋白去乙酰化酶（hdac）的翻译修饰，对于调节基因表达至关重要，并且对心血管疾病（CVD）具有重要意义。由于hdac在基因表达调控和细胞功能中的关键作用，hdac与CVD之间的关系引起了人们极大的研究兴趣。异常的HDAC活性与CVD的多种病理过程有关，包括炎症、内皮功能障碍、肥大、纤维化和动脉粥样硬化。本文探讨了不同HDAC亚型影响心血管病理的分子机制，重点介绍了临床前和临床研究的证据。新出现的数据表明，HDAC抑制剂可以通过调节这些过程和改善心血管健康来提供治疗潜力。然而，HDAC抑制在CVD中的精确的亚型特异性作用和治疗窗口仍有待阐明。此外，研究对于确定hdac与心血管健康之间的关键和复杂关系至关重要，这可能为CVD治疗的新型靶向干预铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Molecular and Cellular Biochemistry 生物-细胞生物学

CiteScore

8.30

自引率

2.30%

发文量

293

审稿时长

1.7 months

期刊介绍： Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.