Precursor plasma cell disorders: Classification, risk stratification, and emerging role of early interception

IF 2.2 4区医学 Q3 HEMATOLOGY

Best Practice & Research Clinical Haematology Pub Date : 2025-07-09 DOI:10.1016/j.beha.2025.101641

Tarek H. Mouhieddine , Irene M. Ghobrial , Omar Nadeem

引用次数: 0

Abstract

Precursor plasma cell disorders include monoclonal gammopathy of undermined significance (MGUS) and smoldering multiple myeloma (SMM). These conditions carry a variable risk of progression to symptomatic myeloma and there are ongoing efforts to improve risk stratification to identify patients that are at highest risk of progression. Advanced imaging plays a crucial role in diagnosis and monitoring, and more sensitive tools to measure serum monoclonal proteins and circulating tumor cells are being developed. The data for early intervention in SMM continues to evolve, with several phase III studies demonstrating benefit compared to observation. There are ongoing studies evaluating the role of combination and T cell immunotherapies in patients with precursor plasma cell disorders. This review will highlight the current state of the art tools in diagnosis, risk stratification, and data for early interception in patients with precursor plasma cell dyscrasias.

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前体浆细胞疾病：分类、风险分层和早期阻断的新作用

前体浆细胞疾病包括单克隆性显著性γ病（MGUS）和阴燃性多发性骨髓瘤（SMM）。这些疾病进展为症状性骨髓瘤的风险是可变的，目前正在努力改善风险分层，以确定进展风险最高的患者。先进的影像学在诊断和监测中起着至关重要的作用，更敏感的工具来测量血清单克隆蛋白和循环肿瘤细胞正在开发中。SMM早期干预的数据在不断发展，与观察相比，一些III期研究显示了益处。目前正在进行的研究评估联合免疫疗法和T细胞免疫疗法在前体浆细胞疾病患者中的作用。本综述将重点介绍前体浆细胞异常患者在诊断、风险分层和早期阻断方面的最新工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research Clinical Haematology 医学-血液学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.