{"title":"Beta-alanine as a Potential Treatment for Aquagenic Pruritus: An Online Social Media-based Survey Study.","authors":"Antonio Concistrè","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Aquagenic pruritus (AP), characterized by intense itching upon water contact, poses a significant challenge for effective treatment, especially in its idiopathic form. This study investigated beta-alanine as a potential therapeutic option for AP.</p><p><strong>Methods: </strong>A comprehensive online survey was conducted among 75 self-reported patients with AP, predominantly Italian, recruited through a dedicated social media group to assess the efficacy and side-effects of beta-alanine supplementation.</p><p><strong>Results: </strong>Beta-alanine emerged as a prevalent choice among participants, demonstrating promising efficacy with an average relief rating of 8.84 out of 10 (95% CI: 8.52-9.16). The average daily dosage during pruritus exacerbation was 1.59 grams (SD ± 0.73). Transient paresthesia represented the primary side-effect, reported by 39.6% of users.</p><p><strong>Conclusion: </strong>While further controlled trials are necessary, this anecdotal evidence underscores beta-alanine's potential as a valuable adjunct to AP management, addressing a condition that profoundly impacts quality of life.</p>","PeriodicalId":94367,"journal":{"name":"Acta dermatovenerologica Croatica : ADC","volume":"32 4","pages":"123-134"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta dermatovenerologica Croatica : ADC","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Aquagenic pruritus (AP), characterized by intense itching upon water contact, poses a significant challenge for effective treatment, especially in its idiopathic form. This study investigated beta-alanine as a potential therapeutic option for AP.
Methods: A comprehensive online survey was conducted among 75 self-reported patients with AP, predominantly Italian, recruited through a dedicated social media group to assess the efficacy and side-effects of beta-alanine supplementation.
Results: Beta-alanine emerged as a prevalent choice among participants, demonstrating promising efficacy with an average relief rating of 8.84 out of 10 (95% CI: 8.52-9.16). The average daily dosage during pruritus exacerbation was 1.59 grams (SD ± 0.73). Transient paresthesia represented the primary side-effect, reported by 39.6% of users.
Conclusion: While further controlled trials are necessary, this anecdotal evidence underscores beta-alanine's potential as a valuable adjunct to AP management, addressing a condition that profoundly impacts quality of life.
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