Glioma mimicking a cystic infectious disease: A case report of multifocal, multicentric cystic glioblastoma.

Surgical neurology international Pub Date : 2025-06-20 eCollection Date: 2025-01-01 DOI:10.25259/SNI_56_2025

Daniel Kiss-Bodolay, Marc Weiner, Kristof Egervari, Gilles Eperon, Maria Isabel Vargas, Denis Migliorini, Johannes Lobrinus, Stephan Harbarth, Philippe Bijlenga

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Abstract

Background: Glioblastoma multiforme (GBM) is a highly aggressive malignant tumor known to be a great mimicker. Multicystic metastasis and cystic GBM are not rare but multicystic diffuse GBM was never reported before.

Case description: We describe here the clinical course, the radiological characteristics, and the management of a patient with a diffuse cystic brain lesion. Even though the comprehensive bacterial, fungal, and parasitic work-up came back negative twice, the radiological and biological findings of the case presented in this work mislead an experienced multidisciplinary team. In a somewhat unexpected way, the pathological results showed a high-grade glial tumor.

Conclusion: The case reported herein is an important reminder of the highly multimorph characteristics of GBM and the challenging differential diagnosis of cystic brain lesions.

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模拟囊性感染性疾病的胶质瘤：多灶、多中心囊性胶质母细胞瘤1例报告。

背景：多形性胶质母细胞瘤（GBM）是一种高度侵袭性的恶性肿瘤，被认为是一个伟大的模仿者。多囊性转移和囊性GBM并不罕见，但多囊性弥漫性GBM从未报道过。病例描述：我们在这里描述了一个弥漫性囊性脑病变患者的临床过程、放射学特征和治疗。尽管全面的细菌、真菌和寄生虫检查结果两次呈阴性，但本研究中提出的病例放射学和生物学结果误导了一个经验丰富的多学科团队。出乎意料的是，病理结果显示为高级别神经胶质瘤。结论：本文报告的病例提示了GBM的高度多形态特征和囊性脑病变的鉴别诊断挑战性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Surgical neurology international

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