Gastric Cancer Mortality in the United States: A Two-Decade Analysis of Trends and Disparities (1999-2020).

IF 1.6 4区 医学 Q4 ONCOLOGY
Muzamil Khan, Abu Huraira Bin Gulzar, Fatima Shahid, Belal Hamed Mohamed, Amar Lal, Shree Rath, Nouman Aziz, Waseem Nabi, Anees Cheema, Usama Ali, Adnan Bhat
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引用次数: 0

Abstract

Objectives: Gastric cancer mortality has declined in recent decades, yet sociodemographic disparities remain. This study analyzed national trends in gastric cancer mortality among US adults, with stratification by demographic and geographic factors.

Methods: We examined gastric cancer deaths (ICD-10 C16) in adults aged ≥25 years using CDC WONDER data from 1999 to 2020. Mortality trends were analyzed by age, sex, race/ethnicity, region, and urbanization using joinpoint regression to calculate annual and average annual percent changes (APC, AAPC).

Results: From 1999 to 2020, there were 276,023 gastric cancer deaths. Mortality declined more in males (AAPC: -2.97 [95% CI: -3.15 to -2.79]) than females (-2.42 [-2.64 to -2.21]). The largest declines were among Asians (-3.83 [-4.08 to -3.56]) and Blacks (-3.25 [-3.49 to -3.02]), followed by Whites (-2.96 [-3.13 to -2.87]) and Hispanics (-2.31 [-2.58 to -2.06]). Metropolitan areas saw greater declines (-2.72 [-2.83 to -2.62]) than rural areas (-2.41 [-2.68 to -2.12]). By region, the Northeast showed the steepest decline (-3.16 [-3.34 to -2.99]), followed by the Midwest, South, and West. Notably, mortality increased among adults aged 25 to 34 years (AAPC: 0.38 [-1.24 to 2.70]) and 35 to 44 years (0.87 [0.12 to 1.73]).

Conclusions: Gastric cancer mortality declined overall but with persistent disparities. Rising rates among younger adults and slower declines in rural and western regions warrant further investigation and targeted interventions.

美国胃癌死亡率:趋势和差异的二十年分析(1999-2020)
目的:近几十年来胃癌死亡率有所下降,但社会人口差异仍然存在。本研究分析了美国成年人胃癌死亡率的全国趋势,并根据人口统计学和地理因素进行了分层。方法:我们使用1999年至2020年CDC WONDER数据对年龄≥25岁的成年人胃癌死亡(ICD-10 C16)进行了调查。死亡率趋势按年龄、性别、种族/民族、地区和城市化进行分析,使用联结点回归计算年和平均年百分比变化(APC, AAPC)。结果:1999年至2020年,全国共有276023例胃癌死亡。男性死亡率(AAPC: -2.97 [95% CI: -3.15至-2.79])比女性(-2.42[-2.64至-2.21])下降更多。跌幅最大的是亚洲人(-3.83[-4.08至-3.56])和黑人(-3.25[-3.49至-3.02]),其次是白人(-2.96[-3.13至-2.87])和西班牙裔(-2.31[-2.58至-2.06])。首都地区的跌幅(-2.72[-2.83至-2.62])比农村地区(-2.41[-2.68至-2.12])更大。按地区划分,东北部降幅最大(-3.16[-3.34至-2.99]),其次是中西部、南部和西部。值得注意的是,25 ~ 34岁(AAPC: 0.38[-1.24 ~ 2.70])和35 ~ 44岁(0.87[0.12 ~ 1.73])的死亡率有所增加。结论:胃癌死亡率总体下降,但差异持续存在。年轻人发病率上升,农村和西部地区发病率下降缓慢,需要进一步调查和有针对性的干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.90
自引率
0.00%
发文量
130
审稿时长
4-8 weeks
期刊介绍: ​​​​​​​American Journal of Clinical Oncology is a multidisciplinary journal for cancer surgeons, radiation oncologists, medical oncologists, GYN oncologists, and pediatric oncologists. The emphasis of AJCO is on combined modality multidisciplinary loco-regional management of cancer. The journal also gives emphasis to translational research, outcome studies, and cost utility analyses, and includes opinion pieces and review articles. The editorial board includes a large number of distinguished surgeons, radiation oncologists, medical oncologists, GYN oncologists, pediatric oncologists, and others who are internationally recognized for expertise in their fields.
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