Gustavo A Medina, Maximiliano Fenucci, Sebastián Magri, Marcelo Abdala, Tamara Arias, Brian Abdala, Leila Abbas, Vinod Chandran, Rodrigo García-Salinas
{"title":"Distinctive clinical patterns and management trends in late-onset psoriatic arthritis: data from Argentina's RECCAPSO registry.","authors":"Gustavo A Medina, Maximiliano Fenucci, Sebastián Magri, Marcelo Abdala, Tamara Arias, Brian Abdala, Leila Abbas, Vinod Chandran, Rodrigo García-Salinas","doi":"10.1177/1759720X251356206","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Late-onset psoriatic arthritis (LO-PsA) has been underexplored despite its growing prevalence in aging populations. Understanding its distinct clinical presentation and treatment patterns is essential to optimize care in this subgroup.</p><p><strong>Objectives: </strong>To describe the demographic, clinical, and therapeutic features of patients with LO-PsA compared to early onset PsA (EO-PsA) using data from the Argentine RECCAPSO registry.</p><p><strong>Design: </strong>Ambispective, multicenter analysis with a cross-sectional evaluation.</p><p><strong>Methods: </strong>Patients with PsA were categorized into EO-PsA (age of onset ⩽60 years) and LO-PsA (>60 years). Demographics, clinical characteristics, disease activity, and treatment variables were compared between groups using appropriate statistical tests. A multivariate logistic regression model was constructed to identify factors independently associated with LO-PsA.</p><p><strong>Results: </strong>A total of 271 PsA patients were included (EO-PsA: <i>n</i> = 184; LO-PsA: <i>n</i> = 87). LO-PsA patients had higher frequencies of hypertension (50% vs 21.4%, <i>p</i> < 0.001), diabetes (22.1% vs 7.9%, <i>p</i> = 0.007), and oligoarticular presentation (57.4% vs 40.5%, <i>p</i> = 0.03), and were less likely to receive b/tsDMARDs (42.6% vs 58.7%, <i>p</i> = 0.02). In multivariate analysis, hypertension (OR: 4.69, 95% CI: 1.83-12.03) and diabetes (OR: 14.83, 95% CI: 2.36-93.05) were independently associated with LO-PsA.</p><p><strong>Conclusion: </strong>LO-PsA presents a distinct clinical profile characterized by greater comorbidity burden and lower exposure to advanced therapies. These findings highlight the need for tailored management strategies in older adults with PsA.</p>","PeriodicalId":23056,"journal":{"name":"Therapeutic Advances in Musculoskeletal Disease","volume":"17 ","pages":"1759720X251356206"},"PeriodicalIF":3.4000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254671/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Musculoskeletal Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/1759720X251356206","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Late-onset psoriatic arthritis (LO-PsA) has been underexplored despite its growing prevalence in aging populations. Understanding its distinct clinical presentation and treatment patterns is essential to optimize care in this subgroup.
Objectives: To describe the demographic, clinical, and therapeutic features of patients with LO-PsA compared to early onset PsA (EO-PsA) using data from the Argentine RECCAPSO registry.
Design: Ambispective, multicenter analysis with a cross-sectional evaluation.
Methods: Patients with PsA were categorized into EO-PsA (age of onset ⩽60 years) and LO-PsA (>60 years). Demographics, clinical characteristics, disease activity, and treatment variables were compared between groups using appropriate statistical tests. A multivariate logistic regression model was constructed to identify factors independently associated with LO-PsA.
Results: A total of 271 PsA patients were included (EO-PsA: n = 184; LO-PsA: n = 87). LO-PsA patients had higher frequencies of hypertension (50% vs 21.4%, p < 0.001), diabetes (22.1% vs 7.9%, p = 0.007), and oligoarticular presentation (57.4% vs 40.5%, p = 0.03), and were less likely to receive b/tsDMARDs (42.6% vs 58.7%, p = 0.02). In multivariate analysis, hypertension (OR: 4.69, 95% CI: 1.83-12.03) and diabetes (OR: 14.83, 95% CI: 2.36-93.05) were independently associated with LO-PsA.
Conclusion: LO-PsA presents a distinct clinical profile characterized by greater comorbidity burden and lower exposure to advanced therapies. These findings highlight the need for tailored management strategies in older adults with PsA.
背景：迟发性银屑病关节炎（LO-PsA）在老年人群中的发病率越来越高，但对其的研究还不够充分。了解其独特的临床表现和治疗模式对于优化该亚组的护理至关重要。目的：利用阿根廷RECCAPSO登记的数据，描述LO-PsA患者与早发性PsA （EO-PsA）患者的人口学、临床和治疗特征。设计：双视角、多中心分析和横断面评价。方法：将PsA患者分为eo型PsA（发病年龄≥60岁）和lo型PsA（发病年龄≥60岁）。使用适当的统计检验比较两组间的人口统计学、临床特征、疾病活动性和治疗变量。建立多元逻辑回归模型以确定与LO-PsA独立相关的因素。结果：共纳入271例PsA患者(EO-PsA: n = 184；LO-PsA: n = 87)。LO-PsA患者高血压（50% vs 21.4%, p = 0.007）和少关节表现（57.4% vs 40.5%, p = 0.03）的频率更高，接受b/tsDMARDs的可能性更低（42.6% vs 58.7%, p = 0.02）。在多变量分析中，高血压（OR: 4.69, 95% CI: 1.83-12.03）和糖尿病（OR: 14.83, 95% CI: 2.36-93.05）与LO-PsA独立相关。结论：LO-PsA表现出明显的临床特征，其特点是更大的合并症负担和更低的先进治疗暴露。这些发现强调了针对老年PsA患者定制管理策略的必要性。
期刊介绍：
Therapeutic Advances in Musculoskeletal Disease delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of musculoskeletal disease.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
