Genetic Association Between Sleep Traits and Vertigo Risk: A Two-Sample Bidirectional Mendelian Randomization Study.

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current molecular medicine Pub Date : 2025-07-10 DOI:10.2174/0115665240358943250612115854

Weimin Xu, E Tian, Jun Wang, Xixi Yu, Zhaoqi Guo, Jingyu Chen, Sulin Zhang

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引用次数: 0

Abstract

Background: Observational studies suggest the potential association between sleep traits and vertigo; however, causal evidence remains limited.

Objective: This study aimed to explore the relationship between genetically predicted sleep traits and vertigo with the Mendelian randomization (MR) method.

Methods: Instrumental variables for sleep traits (snoring, sleep duration, insomnia, daytime sleepiness, daytime napping, and chronotype) were adopted from genomewide association studies (GWAS) data of European ancestry from UK Biobank. The summary-level datasets of vertigo were retrieved from the GWAS of FinnGen. Inversevariance weighted (IVW) method was adopted as the main analysis.

Results: IVW analysis revealed a significant association between genetically predicted daytime napping (OR = 1.51, 95% CI =1.08-2.12, P = 0.016) and chronotype (OR = 1.13, 95% CI =1.01-1.26, P = 0.033), both of which were associated with an increased risk of vertigo. However, we did not find evidence for a causal effect of snoring, overall sleep duration, long sleep duration, short sleep duration, insomnia, and excessive daytime sleepiness on vertigo. No reverse causality was detected.

Conclusion: Our findings suggest that abnormal sleep patterns may serve as risk factors for vertigo disorders and offer opportunities for the prevention and management of vertigo disorders.

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睡眠特征与眩晕风险的遗传关联：一项双样本双向孟德尔随机化研究。

背景：观察性研究表明，睡眠特征与眩晕之间存在潜在关联；然而，因果证据仍然有限。目的：采用孟德尔随机化方法探讨遗传预测睡眠特征与眩晕的关系。方法：睡眠特征的工具变量（打鼾、睡眠持续时间、失眠、白天嗜睡、白天午睡和睡眠类型）采用来自英国生物银行欧洲血统全基因组关联研究（GWAS）数据。眩晕的概要级数据集从FinnGen的GWAS中检索。采用逆方差加权法（IVW）作为主要分析方法。结果：IVW分析显示，基因预测的白天午睡（OR = 1.51, 95% CI =1.08-2.12, P = 0.016）和睡眠类型（OR = 1.13, 95% CI =1.01-1.26, P = 0.033）之间存在显著关联，两者都与眩晕风险增加有关。然而，我们没有发现打鼾、总睡眠时间、长睡眠时间、短睡眠时间、失眠和白天过度嗜睡对眩晕有因果关系的证据。未发现反向因果关系。结论：我们的研究结果提示异常睡眠模式可能是眩晕障碍的危险因素，为眩晕障碍的预防和治疗提供了机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current molecular medicine 医学-医学：研究与实验

CiteScore

5.00

自引率

4.00%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews/ mini-reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.