Association of device measured physical activity with liver fat and stiffness in people with type 1 diabetes.

IF 5.4 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes, Obesity & Metabolism Pub Date : 2025-07-14 DOI:10.1111/dom.16584

Ebaa Al Ozairi, Mohammad Irshad, Jumana Alkandari, Etab Taghadom, Anisha Varghese, Dherar Alroudhan, Nasser Alqattan, Stuart R Gray

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引用次数: 0

Abstract

Aims: This study aimed to investigate the association between physical activity (PA) metrics and liver fat and stiffness in people with type 1 diabetes (T1D).

Materials and methods: People with T1D attending clinics or participating in ongoing research at the Dasman Diabetes Institute in Kuwait were invited to participate. Liver fat fraction and stiffness were assessed using magnetic resonance imaging and elastography, respectively, liver enzymes were quantified and PA metrics were assessed over 7 days with a wrist-worn accelerometer. Associations of PA with liver fat, stiffness and enzyme biomarkers were examined using multiple linear regression.

Results: A total of 173 participants with T1D (mean age: 40.3(14.3) years, mean body mass index (BMI): 28.8(4.8) kg/m², mean HbA1c: 7.7(1.3) %, male: 52%) were included. After adjusting for age, sex and BMI, overall PA was negatively associated with liver fat fraction (B = -0.09, p = 0.04), liver stiffness (B = -0.02, p < 0.001), AST (B = -0.23, p = 0.03) and GGT (B = -0.50, p = 0.03). The intensity gradient (B = -0.40, p = 0.01) and light PA (B = -0.001, p = 0.04) were negatively associated with liver stiffness. Moderate to vigorous physical activity (MVPA) was negatively associated with liver stiffness (B = -0.003, p = 0.001), AST (B = -0.06, p = 0.01) and GGT (B = -0.10, p = 0.02). After mutual adjustment, overall PA remained associated with liver fat (B = -0.13, p = 0.01), stiffness (B = -0.01, p = 0.01) and ALT (B = -0.38, p = 0.04), but no associations remained with the intensity gradient.

Conclusions: Promoting PA, particularly MVPA, in T1D may help with the maintenance of liver health.

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1型糖尿病患者设备测量的体力活动与肝脏脂肪和僵硬的关系

目的：本研究旨在探讨1型糖尿病（T1D）患者身体活动（PA）指标与肝脏脂肪和僵硬之间的关系。材料和方法：邀请在科威特达斯曼糖尿病研究所就诊或参与正在进行的研究的T1D患者参加。通过磁共振成像和弹性成像分别评估肝脏脂肪分数和硬度，量化肝酶，并通过腕带加速度计评估7天内的PA指标。使用多元线性回归检测PA与肝脏脂肪、硬度和酶生物标志物的关系。结果：共纳入173例T1D患者(平均年龄：40.3（14.3）岁，平均体重指数（BMI）： 28.8（4.8) kg/m2，平均糖化血红蛋白：7.7(1.3)%，男性：52%）。在调整了年龄、性别和BMI后，总体PA与肝脏脂肪分数（B = -0.09, p = 0.04）和肝脏硬度（B = -0.02, p）呈负相关。结论：在T1D中促进PA，特别是MVPA可能有助于维持肝脏健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Obesity & Metabolism 医学-内分泌学与代谢

CiteScore

10.90

自引率

6.90%

发文量

319

审稿时长

3-8 weeks

期刊介绍： Diabetes, Obesity and Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. The journal prioritises high-quality original research that reports on the effects of new or existing therapies, including dietary, exercise and lifestyle (non-pharmacological) interventions, in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. ‘Metabolism’ may relate to lipids, bone and drug metabolism, or broader aspects of endocrine dysfunction. Preclinical pharmacology, pharmacokinetic studies, meta-analyses and those addressing drug safety and tolerability are also highly suitable for publication in this journal. Original research may be published as a main paper or as a research letter.