Changes in adiposity indices over 10 years and risk of type 2 diabetes: The Whitehall II cohort study.

IF 5.4 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes, Obesity & Metabolism Pub Date : 2025-07-14 DOI:10.1111/dom.16615

Cunrong Huang, Yuntao Chen, Annie Britton

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引用次数: 0

Abstract

Aims: Common adiposity indices that are used to assess obesity include body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WHtR). We aim to investigate change rates of the three indices in British middle-aged adults and compare effects of different adiposity indices' changes on incident type 2 diabetes.

Materials and methods: Three repeated measures of BMI, WC and WHtR were collected over a decade (1991-2004) in 5666 participants without diabetes from the Whitehall II cohort study of British civil servants. Linear mixed-effects models were used to estimate standardised individual change rates of the three indices, and participants were then followed up for incident diabetes until 2023. We examined the prospective associations between change rates of the three indices and diabetes by Cox regression analysis.

Results: The mean change rates for BMI, WC and WHtR were 0.04, 0.06 and 0.07 standard deviation (SD)/year, respectively. There were 633 incident diabetes cases after a median follow-up of 17.6 years. For every 1-SD increase per decade, WC change (HR: 3.01, 95% CI: 2.15-4.22) was associated with a higher diabetes risk than changes in WHtR (HR: 2.67, 95% CI: 2.00-3.55), and BMI (HR: 1.98, 95% CI: 1.53-2.56). No significant interactions were found between the change rates and either sex or age.

Conclusions: The changes in WC and WHtR over a decade were associated with a higher risk of developing diabetes than the change in BMI in this British adult population. Routine monitoring of WC in general practice may provide more benefit than BMI management alone in preventing diabetes.

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10年来肥胖指数的变化和2型糖尿病的风险：Whitehall II队列研究

目的：用于评估肥胖的常用肥胖指标包括体重指数（BMI）、腰围（WC）和腰高比（WHtR）。我们的目的是调查这三个指标在英国中年人中的变化率，并比较不同肥胖指标的变化对2型糖尿病的影响。材料和方法：从英国公务员Whitehall II队列研究中收集了5666名非糖尿病患者的BMI、WC和WHtR三项重复测量数据，历时10年（1991-2004）。使用线性混合效应模型来估计这三个指标的标准化个体变化率，然后随访参与者的糖尿病事件，直到2023年。我们通过Cox回归分析检验了这三个指标的变化率与糖尿病之间的潜在关联。结果：BMI、WC和WHtR的平均变化率分别为0.04、0.06和0.07标准差(SD)/年。在17.6年的中位随访后，有633例糖尿病病例。每10年每增加1个标准差，腰围变化（HR: 3.01, 95% CI: 2.15-4.22）与WHtR （HR: 2.67, 95% CI: 2.00-3.55）和BMI （HR: 1.98, 95% CI: 1.53-2.56）的变化相关的糖尿病风险更高。在变化率和性别或年龄之间没有发现显著的相互作用。结论：在英国成年人群中，十年来腰围和腰臀比的变化与患糖尿病的风险高于BMI的变化相关。在一般实践中，常规监测WC可能比单独管理BMI在预防糖尿病方面更有益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Obesity & Metabolism 医学-内分泌学与代谢

CiteScore

10.90

自引率

6.90%

发文量

319

审稿时长

3-8 weeks

期刊介绍： Diabetes, Obesity and Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. The journal prioritises high-quality original research that reports on the effects of new or existing therapies, including dietary, exercise and lifestyle (non-pharmacological) interventions, in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. ‘Metabolism’ may relate to lipids, bone and drug metabolism, or broader aspects of endocrine dysfunction. Preclinical pharmacology, pharmacokinetic studies, meta-analyses and those addressing drug safety and tolerability are also highly suitable for publication in this journal. Original research may be published as a main paper or as a research letter.