Controlling Drug Release From Supramolecular Polymer Surfaces by a Click-To-Release Reaction

IF 3.9 3区 化学 Q2 POLYMER SCIENCE
Maritza M. Rovers, Joyce E. P. Brouns, Fenna W. B. Craenmehr, Marc Robillard, Joris W. Peeters, Henk M. Janssen, Patricia Y. W. Dankers
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Abstract

Here, we introduce the combination of reactive supramolecular additives with a covalent click-to-release reaction. Hereto, a reactive supramolecular trans-cyclooctene (TCO) additive is synthesized to trigger the release of a cytotoxic drug from a ureido-pyrimidinone (UPy) based supramolecular material by soluble tetrazine (Tz) administration. Therefore, two reactive additives are designed. First, to monitor the reaction, a fluorescent UPy-TCO-Cy5 additive is synthesized and incorporated in a supramolecular polymer material. Reaction with Tz shows an increase in fluorescent signal in the supernatant, indicating successful release. Next, a cytotoxic UPy-TCO-MMC additive is synthesized and incorporated in a supramolecular polymer material where reaction with Tz results in the cell death of breast cancer cells. This study presents a new strategy for on-demand localized drug delivery to cells from a supramolecular surface.

Abstract Image

通过点击释放反应控制超分子聚合物表面的药物释放
在这里,我们介绍了反应性超分子添加剂与共价点击释放反应的组合。本文合成了一种反应性的超分子反式环烯(TCO)添加剂,通过可溶性四嗪(Tz)给药,从脲嘧啶(UPy)基超分子材料中触发细胞毒性药物的释放。因此,设计了两种活性添加剂。首先,为了监测反应,合成了一种荧光UPy-TCO-Cy5添加剂并将其掺入超分子聚合物材料中。与Tz反应,上清液荧光信号增强,表明释放成功。接下来,合成一种细胞毒性UPy-TCO-MMC添加剂,并将其掺入一种超分子聚合物材料中,与Tz发生反应,导致乳腺癌细胞死亡。本研究提出了一种从超分子表面按需定位药物递送到细胞的新策略。
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来源期刊
Journal of Polymer Science
Journal of Polymer Science POLYMER SCIENCE-
CiteScore
6.30
自引率
5.90%
发文量
264
期刊介绍: Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology. As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology.
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