Maritza M. Rovers, Joyce E. P. Brouns, Fenna W. B. Craenmehr, Marc Robillard, Joris W. Peeters, Henk M. Janssen, Patricia Y. W. Dankers
{"title":"Controlling Drug Release From Supramolecular Polymer Surfaces by a Click-To-Release Reaction","authors":"Maritza M. Rovers, Joyce E. P. Brouns, Fenna W. B. Craenmehr, Marc Robillard, Joris W. Peeters, Henk M. Janssen, Patricia Y. W. Dankers","doi":"10.1002/pol.20250133","DOIUrl":null,"url":null,"abstract":"<p>Here, we introduce the combination of reactive supramolecular additives with a covalent click-to-release reaction. Hereto, a reactive supramolecular trans-cyclooctene (TCO) additive is synthesized to trigger the release of a cytotoxic drug from a ureido-pyrimidinone (UPy) based supramolecular material by soluble tetrazine (Tz) administration. Therefore, two reactive additives are designed. First, to monitor the reaction, a fluorescent UPy-TCO-Cy5 additive is synthesized and incorporated in a supramolecular polymer material. Reaction with Tz shows an increase in fluorescent signal in the supernatant, indicating successful release. Next, a cytotoxic UPy-TCO-MMC additive is synthesized and incorporated in a supramolecular polymer material where reaction with Tz results in the cell death of breast cancer cells. This study presents a new strategy for on-demand localized drug delivery to cells from a supramolecular surface.</p>","PeriodicalId":16888,"journal":{"name":"Journal of Polymer Science","volume":"63 14","pages":"2934-2943"},"PeriodicalIF":3.9000,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/pol.20250133","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Polymer Science","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/pol.20250133","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
Here, we introduce the combination of reactive supramolecular additives with a covalent click-to-release reaction. Hereto, a reactive supramolecular trans-cyclooctene (TCO) additive is synthesized to trigger the release of a cytotoxic drug from a ureido-pyrimidinone (UPy) based supramolecular material by soluble tetrazine (Tz) administration. Therefore, two reactive additives are designed. First, to monitor the reaction, a fluorescent UPy-TCO-Cy5 additive is synthesized and incorporated in a supramolecular polymer material. Reaction with Tz shows an increase in fluorescent signal in the supernatant, indicating successful release. Next, a cytotoxic UPy-TCO-MMC additive is synthesized and incorporated in a supramolecular polymer material where reaction with Tz results in the cell death of breast cancer cells. This study presents a new strategy for on-demand localized drug delivery to cells from a supramolecular surface.
期刊介绍:
Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology.
As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology.