Cardiorespiratory fitness modifies the relationship between arterial stiffness and cerebral blood flow independent of physical activity

IF 4.9 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Translational Research and Clinical Interventions Pub Date : 2025-07-14 DOI:10.1002/trc2.70130

Brianne M. Breidenbach, Ira Driscoll, Matthew P. Glittenberg, Adam J. Paulsen, Sara Fernandes-Taylor, Tarun Naren, Grant S. Roberts, Talia L. Brach, Mackenzie M. Jarchow, Leah E. Symanski, Anna Y. Gaul, Sarah R. Lose, Leonardo A. Rivera-Rivera, Sterling C. Johnson, Sanjay Asthana, Bradley T. Christian, Dane B. Cook, Oliver Wieben, Ozioma C. Okonkwo

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引用次数: 0

Abstract

INTRODUCTION

Central arterial stiffness and cerebral blood flow (CBF) are inversely related. Poor cardiorespiratory fitness (CRF) and low physical activity (PA) are related to both higher arterial stiffness and lower CBF. The present study examined (i) whether CRF or PA moderate the relationship between arterial stiffness and CBF, and (ii) whether the intensity or the type of PA needs to be considered.

METHODS

Participants (N = 78, Mean_AGE = 64.2±6.14, 72% female) from the Wisconsin Registry for Alzheimer's Prevention and the Wisconsin Alzheimer's Disease Research Center were categorized into low, average, and high fitness groups based on maximal graded exercise treadmill test performance. PA was assessed using the CHAMPS (Community Health Activities Model Program for Seniors) questionnaire. Based on hours/week, participants were classified as meeting the recommended 2.5 h of moderate intensity PA per week (PA Rec Met). Weekly hours of moderate and low intensity PA were calculated as activities of > 3 or < 3 metabolic equivalents, respectively. Activity type was categorized as exercise-, sports/leisure- and work-related. Arterial stiffness was measured as aortic pulse wave velocity (aoPWV) by 2D phase contrast magnetic resonance imaging (MRI). CBF was assessed by 4D flow MRI in the internal carotid arteries (ICAs), cavernous ICAs, middle cerebral arteries (MCAs), and via two composite measures of total and global flow.

RESULTS

The association between aoPWV and CBF differed by fitness levels, with a negative relationship in the low fitness group and positive relationships in the average and high fitness groups (all Ps<0.05). Significant moderating effects on the relationships between aoPWV and CBF were also observed for PA Rec Met (all Ps<0.05), moderate intensity (p = 0.05), and exercise-related (all p’s < 0.02) PA.

DISCUSSION

Average or high fitness, meeting the PA guidelines, and more specifically, moderate intensity and exercise-related PA seem to attenuate the negative relationship between aoPWV on CBF.

Highlights

Higher cardiorespiratory fitness (CRF) reduces the negative impact of aortic pulse wave velocity (aoPWV) on cerebral blood flow (CBF)
150 min of moderate physical activity (PA) also mitigates this impact, depending on activity type
Innovative methods: use of cardiac magnetic resonance imaging (MRI) for aoPWV assessment
Innovative methods: use of free-breathing acquisition during cardiac MRI
Innovative methods: use of cranial 4D flow MRI for CBF assessment

Abstract Image

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心肺适能改变独立于体力活动的动脉僵硬度和脑血流量之间的关系

中心动脉僵硬度与脑血流量呈负相关。较差的心肺功能（CRF）和较低的身体活动（PA）与较高的动脉硬度和较低的CBF有关。本研究考察了(i) CRF或PA是否调节了动脉僵硬度和CBF之间的关系，以及（ii）是否需要考虑PA的强度或类型。方法来自威斯康辛州阿尔茨海默病预防登记中心和威斯康辛州阿尔茨海默病研究中心的参与者（N = 78，平均年龄= 64.2±6.14,72%为女性）根据最大分级运动跑步机测试成绩分为低、中、高健身组。使用CHAMPS（老年人社区健康活动模式计划）问卷对PA进行评估。根据每周的小时数，参与者被划分为每周2.5小时中等强度的PA （PA Rec Met）。每周中低强度PA的小时数计算为>；3或<；3个代谢当量。活动类型分为运动类、运动/休闲类和工作类。通过二维相对比磁共振成像（MRI）以主动脉脉冲波速度（aoPWV）测量动脉硬度。通过内颈动脉（ICAs）、海绵状ICAs、大脑中动脉（MCAs）的4D血流MRI以及总流量和总流量的两种复合测量来评估CBF。结果aoPWV与CBF的相关性因体能水平的不同而不同，低体能组呈负相关，中等和高体能组呈正相关（p < 0.05）。在PA、Rec、Met（均p 's <0.05）、中等强度（p = 0.05）和运动相关（p 's <0.05）中，aoPWV和CBF之间的关系也有显著的调节作用。0.02)。平均或高水平的健身，满足PA指南，更具体地说，中等强度和运动相关的PA似乎减弱了aoPWV与CBF之间的负相关关系。高心肺适能（CRF）可降低主动脉脉搏波速度（aoPWV）对脑血流量（CBF）的负面影响。150分钟的适度体育活动（PA）也可减轻这种影响，具体取决于活动类型。使用心脏磁共振成像（MRI）评估aoPWV创新方法：在心脏MRI中使用自由呼吸采集创新方法：使用颅四维血流MRI评估CBF

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来源期刊

Alzheimer''s and Dementia: Translational Research and Clinical Interventions Medicine-Psychiatry and Mental Health

CiteScore

10.10

自引率

2.10%

发文量

134

审稿时长

10 weeks

期刊介绍： Alzheimer''s & Dementia: Translational Research & Clinical Interventions (TRCI) is a peer-reviewed, open access,journal from the Alzheimer''s Association®. The journal seeks to bridge the full scope of explorations between basic research on drug discovery and clinical studies, validating putative therapies for aging-related chronic brain conditions that affect cognition, motor functions, and other behavioral or clinical symptoms associated with all forms dementia and Alzheimer''s disease. The journal will publish findings from diverse domains of research and disciplines to accelerate the conversion of abstract facts into practical knowledge: specifically, to translate what is learned at the bench into bedside applications. The journal seeks to publish articles that go beyond a singular emphasis on either basic drug discovery research or clinical research. Rather, an important theme of articles will be the linkages between and among the various discrete steps in the complex continuum of therapy development. For rapid communication among a multidisciplinary research audience involving the range of therapeutic interventions, TRCI will consider only original contributions that include feature length research articles, systematic reviews, meta-analyses, brief reports, narrative reviews, commentaries, letters, perspectives, and research news that would advance wide range of interventions to ameliorate symptoms or alter the progression of chronic neurocognitive disorders such as dementia and Alzheimer''s disease. The journal will publish on topics related to medicine, geriatrics, neuroscience, neurophysiology, neurology, psychiatry, clinical psychology, bioinformatics, pharmaco-genetics, regulatory issues, health economics, pharmacoeconomics, and public health policy as these apply to preclinical and clinical research on therapeutics.