Targeting fructose metabolism for cancer therapy

IF 9.1 1区医学 Q1 ONCOLOGY

Cancer letters Pub Date : 2025-07-11 DOI:10.1016/j.canlet.2025.217914

Qing Zhao , Wen-Lian Chen , Gerry Melino , Wei Jia

引用次数: 0

Abstract

Cancer cells frequently rewire their metabolism to support rapid proliferation and invasion. Our analysis of the most lethal cancers in 2022 reveals a prominent association with dysregulated fructose metabolism. Fructose serves as a crucial alternative energy substrate under nutrient-deprived conditions, promoting the Warburg effect and thereby facilitating tumor growth and metastasis. Moreover, aberrant fructose utilization activates oncogenic mTORC1 signaling, suppresses anti-tumor immune responses, and facilitates tumor progression. Targeting key enzymes and transporters in fructose metabolism presents a promising therapeutic avenue to disrupt tumor bioenergetics and signaling pathways, potentially improving treatment efficacy and patient outcomes.

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针对果糖代谢的癌症治疗

癌细胞经常改变它们的新陈代谢，以支持快速增殖和侵袭。我们对2022年最致命的癌症的分析揭示了与果糖代谢失调的显著关联。在营养缺乏的条件下，果糖作为重要的替代能量底物，促进Warburg效应，从而促进肿瘤的生长和转移。此外，异常的果糖利用激活致癌mTORC1信号，抑制抗肿瘤免疫反应，促进肿瘤进展。靶向果糖代谢中的关键酶和转运体是一种很有前途的治疗途径，可以破坏肿瘤的生物能量学和信号通路，潜在地改善治疗效果和患者预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer letters 医学-肿瘤学

CiteScore

17.70

自引率

2.10%

发文量

427

审稿时长

15 days

期刊介绍： Cancer Letters is a reputable international journal that serves as a platform for significant and original contributions in cancer research. The journal welcomes both full-length articles and Mini Reviews in the wide-ranging field of basic and translational oncology. Furthermore, it frequently presents Special Issues that shed light on current and topical areas in cancer research. Cancer Letters is highly interested in various fundamental aspects that can cater to a diverse readership. These areas include the molecular genetics and cell biology of cancer, radiation biology, molecular pathology, hormones and cancer, viral oncology, metastasis, and chemoprevention. The journal actively focuses on experimental therapeutics, particularly the advancement of targeted therapies for personalized cancer medicine, such as metronomic chemotherapy. By publishing groundbreaking research and promoting advancements in cancer treatments, Cancer Letters aims to actively contribute to the fight against cancer and the improvement of patient outcomes.