Sappanumols A–C, Three Homoisoflavonoids with Antiinflammatory Activities from Sappan lignum

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-14 DOI:10.1021/acs.orglett.5c02020

Qi-Qi Wang, Hao-Jie Liu, Guo-Qing Qin, Chen Hong, Jun Lin, Ping Yang, Yue Shen, Ke-Wu Zeng, Qing-Ying Zhang* and Peng-Fei Tu*,

引用次数: 0

Abstract

Sappanumols A–C (1–3, respectively), three unprecedented homoisoflavonoids, were isolated from Sappan lignum. Their structures were elucidated by comprehensive spectroscopic analysis and ECD computation methods. Compound 3 demonstrated inhibitory effects on LPS-induced NO production in BV-2 cells with an IC₅₀ value of 16.99 μM. Compound 3 decreased the levels of TNF-α and IL-6 in a dose-dependent manner and exhibited significant anti-inflammatory activity in a zebrafish inflammation model.

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三种具有抗炎活性的参木同型异黄酮。

从皂荚木中分离到三种同源异黄酮，分别为A-C（1-3）。通过综合光谱分析和ECD计算方法对其结构进行了分析。化合物3对lps诱导的BV-2细胞NO生成有抑制作用，IC50值为16.99 μM。化合物3在斑马鱼炎症模型中呈剂量依赖性降低TNF-α和IL-6水平，并表现出显著的抗炎活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.