Prognostic value of Naples prognostic score for locally advanced gastric cancer after neoadjuvant chemoimmunotherapy.

IF 2.6 4区医学 Q2 ONCOLOGY

Future oncology Pub Date : 2025-08-01 Epub Date: 2025-07-12 DOI:10.1080/14796694.2025.2532365

Xiong Sun, Tuo Ruan, Yao Lin, Chengguo Li, Qian Shen, Tianhao Li, Jianing Ding, Yuping Yin, Kaixiong Tao

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引用次数: 0

Abstract

Background: The parameters of the Naples prognostic score (NPS) include albumin, total cholesterol, neutrophil-lymphocyte ratio, and lymphocyte-monocyte ratio. This study aimed to investigate the prognostic value of preoperative NPS in locally advanced gastric cancer(LAGC) patients underwent radical resection after neoadjuvant chemoimmunotherapy (NCIT).

Research design and methods: The NPS was calculated and patients were then divided into two groups according to their NPS values as follows: NPS = 0-2 (group 1), NPS = 3-4 (group 2). Univariate and multivariate Cox analysis were used to identify independent prognostic factors associated with overall survival (OS), and time-dependent receiver operating characteristic (t-ROC) curves were carried to evaluate the discriminatory capacity of the prognostic scoring systems.

Results: A total of 117 patients were included in this study. The 1- and 2-year OS rates in group 1 were 100.0% and 95.7%, group 2 exhibited rates of 95.7% and 84.4%. Multivariate cox analysis demonstrated that NPS was an independent prognostic factor of OS (p = 0.009). Furthermore, NPS exhibited better prognostic performance in the prediction of OS than additional prognostic scoring systems.

Conclusions: NPS is a significant prognostic indicator and can be a reliable predictor of survival in LAGC patients underwent radical resection after NCIT.

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那不勒斯预后评分对局部进展期胃癌新辅助化疗免疫治疗的预后价值。

背景：那不勒斯预后评分（Naples prognostic score， NPS）的参数包括白蛋白、总胆固醇、中性粒细胞-淋巴细胞比率和淋巴细胞-单核细胞比率。本研究旨在探讨术前NPS在局部晚期胃癌（LAGC）根治术后新辅助化疗免疫治疗（NCIT）的预后价值。研究设计与方法：计算NPS，根据NPS值将患者分为两组：NPS = 0-2（组1），NPS = 3-4（组2）。采用单因素和多因素Cox分析来确定与总生存期（OS）相关的独立预后因素，并采用时间相关的受试者工作特征（t-ROC）曲线来评估预后评分系统的区分能力。结果：本研究共纳入117例患者。1组1年、2年生存率分别为100.0%、95.7%，2组分别为95.7%、84.4%。多因素cox分析显示NPS是OS的独立预后因素（p = 0.009）。此外，NPS在预测OS方面表现出比其他预后评分系统更好的预后性能。结论：NPS是一个重要的预后指标，可以可靠地预测NCIT后根治性切除的LAGC患者的生存。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future oncology ONCOLOGY-

CiteScore

5.40

自引率

3.00%

发文量

335

审稿时长

4-8 weeks

期刊介绍： Future Oncology (ISSN 1479-6694) provides a forum for a new era of cancer care. The journal focuses on the most important advances and highlights their relevance in the clinical setting. Furthermore, Future Oncology delivers essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community. The journal takes a forward-looking stance toward the scientific and clinical issues, together with the economic and policy issues that confront us in this new era of cancer care. The journal includes literature awareness such as the latest developments in radiotherapy and immunotherapy, concise commentary and analysis, and full review articles all of which provide key findings, translational to the clinical setting.