Adverse Effects and Precautionary Measures for Isotretinoin Use in Patients with Acne Vulgaris: A Single-Center Study.

IF 2.4 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Mohammed Saif Anaam, Dalia A AlShibl, Saeed Alfadly, Munirah Yousef Aloyuni, Fawaz Hamdan Al Harbi, Hussam Alhmoud, Ibrahim S Alhomoud, Waleed Mohammad Altowayan
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引用次数: 0

Abstract

Background: Oral isotretinoin is an effective treatment for refractory and moderate acne unresponsive to conventional therapies, considered the most effective option for such cases.

Objective: This study aimed to evaluate the knowledge, concerns, and experiences of acne patients undergoing isotretinoin treatment in Qassim, Saudi Arabia, with a focus on commonly reported adverse effects.

Methods: A cross-sectional study was conducted from December 2023 to February 2024 using a self-administered questionnaire. This study targeted male and female acne vulgaris patients from the Qassim region attending the outpatient dermatology clinic at King Saud Hospital (KSH).

Results: A total of 131 acne patients participated. Of these, 97.7% had heard of isotretinoin, and 92.4% were aware of its side effects. The most common sources of information were colleagues, friends, or family (37.4%), followed by previous use (26%) and healthcare professionals (24%). The most frequently reported side effect was dryness (51.9%), followed by liver function changes (24.4%) and fetal abnormalities (13%). There was a significant association between educational level and knowledge of isotretinoin's side effects (p = 0.003) and awareness of specific side effects (p < 0.001).

Conclusion: Most acne patients had sufficient knowledge of isotretinoin and its adverse effects, with dryness being the most commonly reported side effect. The primary sources of information were non-medical, highlighting the need for health education to ensure informed and safe isotretinoin use.

寻常痤疮患者使用异维甲酸的不良反应和预防措施:一项单中心研究。
背景:口服异维甲酸是治疗对常规疗法无反应的难治性和中度痤疮的有效方法,被认为是此类病例最有效的选择。目的:本研究旨在评估沙特阿拉伯卡西姆接受异维甲酸治疗的痤疮患者的知识、担忧和经历,重点关注常见的不良反应。方法:于2023年12月至2024年2月采用自填问卷进行横断面研究。本研究的对象是在沙特国王医院(KSH)皮肤科门诊就诊的卡西姆地区的男性和女性寻常痤疮患者。结果:共131例痤疮患者参与。其中97.7%的人听说过异维甲酸,92.4%的人知道它的副作用。最常见的信息来源是同事、朋友或家人(37.4%),其次是以前的使用(26%)和医疗保健专业人员(24%)。最常见的副作用是干燥(51.9%),其次是肝功能改变(24.4%)和胎儿异常(13%)。受教育程度与异维甲酸副作用知识(p = 0.003)和特定副作用意识(p < 0.001)之间存在显著相关。结论:大多数痤疮患者对异维甲酸及其副作用有足够的了解,其中干燥是最常见的副作用。信息的主要来源是非医疗的,这突出表明需要进行健康教育,以确保知情和安全使用异维甲酸。
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来源期刊
Healthcare
Healthcare Medicine-Health Policy
CiteScore
3.50
自引率
7.10%
发文量
0
审稿时长
47 days
期刊介绍: Healthcare (ISSN 2227-9032) is an international, peer-reviewed, open access journal (free for readers), which publishes original theoretical and empirical work in the interdisciplinary area of all aspects of medicine and health care research. Healthcare publishes Original Research Articles, Reviews, Case Reports, Research Notes and Short Communications. We encourage researchers to publish their experimental and theoretical results in as much detail as possible. For theoretical papers, full details of proofs must be provided so that the results can be checked; for experimental papers, full experimental details must be provided so that the results can be reproduced. Additionally, electronic files or software regarding the full details of the calculations, experimental procedure, etc., can be deposited along with the publication as “Supplementary Material”.
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