Integrating multi-omics analysis to uncover the impact of PLXNA1 on the progression of esophageal cancer cells

IF 3.4 2区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Genomics Pub Date : 2025-07-09 DOI:10.1016/j.ygeno.2025.111081

Zhichao Hou , Tangjuan Zhang , Chunyang Zhang , Zheng Ding , Peng Wang , Xue Pan , Xiangnan Li

引用次数: 0

Abstract

Transcriptomics, proteomics, phosphoproteomics, and comprehensive multi-omics analysis were conducted to investigate the relationship between Plexin A1 (PLXNA1) and esophageal cancer (EC) cells. The positive rate of PLXNA1 in EC tissues was significantly high than in adjacent normal tissue. Knocking down PLXNA1 in EC cells led to increased apoptosis and decreased proliferation, invasion, and migration. Analyses revealed that PLXNA1 knockdown influenced cellular transcriptional regulation and cancer-related pathways. Elevated expression of PLXNA1 in patients with EC correlates with survival outcomes. PLXNA1 plays a crucial role in transcriptional regulation and cancer pathways in EC. The expression of PLXNA1 was elevated in patients with EC and might play a key role in EC by regulating the transcriptional process and carcinogenic pathways.

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结合多组学分析揭示PLXNA1对食管癌细胞进展的影响

通过转录组学、蛋白质组学、磷酸化蛋白质组学和综合多组学分析探讨了丛蛋白A1 （PLXNA1）与食管癌（EC）细胞的关系。PLXNA1在EC组织中的阳性率明显高于癌旁正常组织。在EC细胞中敲低PLXNA1导致细胞凋亡增加，增殖、侵袭和迁移减少。分析显示PLXNA1敲低影响细胞转录调控和癌症相关途径。PLXNA1在EC患者中的表达升高与生存结果相关。PLXNA1在EC的转录调控和癌变途径中起关键作用。PLXNA1在EC患者中表达升高，可能通过调控转录过程和致癌途径在EC中发挥关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genomics 生物-生物工程与应用微生物

CiteScore

9.60

自引率

2.30%

发文量

260

审稿时长

60 days

期刊介绍： Genomics is a forum for describing the development of genome-scale technologies and their application to all areas of biological investigation. As a journal that has evolved with the field that carries its name, Genomics focuses on the development and application of cutting-edge methods, addressing fundamental questions with potential interest to a wide audience. Our aim is to publish the highest quality research and to provide authors with rapid, fair and accurate review and publication of manuscripts falling within our scope.