Effects of magnesium concentration on the regulation of nutrition and inflammation in nutritional support for cancer patients.

IF 4.8 2区医学 Q1 ONCOLOGY

Oncologist Pub Date : 2025-07-11 DOI:10.1093/oncolo/oyaf211

Xuelong Li, Wenjing Gong, Xiaoyan Yao, Yuanyuan Gao, Jing Wang

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引用次数: 0

Abstract

Objectives: Magnesium plays a crucial role in metabolic homeostasis and energy balance. This study aims to evaluate the effect of magnesium in regulating nutritional status and inflammatory responses in nutritional support.

Methods: A survey of 86 lung cancer patients was conducted. The oral nutrition supplement group was given an oral nutritional solution that was magnesium rich on the basis of the routine diet in the hospital, while a routine hospital diet was given to the control group. Changes in magnesium concentration, nutritional status and inflammatory indicators were compared between groups.

Results: There was no significant difference in the indicators on 1st day and 10th day compared to the control group (P > 0.05). However, the levels of Mg, ALB, PA, Hb and TLC in the oral nutrition supplement group were significantly increased and the levels of TNF-α, IL-6 and CRP were significantly reduced on the 21st day (P < 0.05).

Conclusions: Changes in magnesium concentration can improve nutritional status and inflammatory response. The synergistic effect of magnesium concentration and nutritional support may open a new avenue for the prevention and treatment of cancer patients.

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镁浓度对肿瘤患者营养支持中营养和炎症调节的影响。

目的：镁在代谢稳态和能量平衡中起着至关重要的作用。本研究旨在评估镁在营养支持中调节营养状况和炎症反应的作用。方法：对86例肺癌患者进行调查。口服营养补充组在医院常规饮食的基础上给予富含镁的口服营养液，对照组给予医院常规饮食。比较各组间镁浓度、营养状况及炎症指标的变化。结果：治疗第1天、第10天各项指标与对照组比较，差异均无统计学意义（P < 0.05）。然而，口服营养补充组在第21天Mg、ALB、PA、Hb和TLC水平显著升高，TNF-α、IL-6和CRP水平显著降低(P)。结论：镁浓度的改变可以改善营养状况和炎症反应。镁浓度与营养支持的协同作用可能为癌症患者的预防和治疗开辟新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncologist 医学-肿瘤学

CiteScore

10.40

自引率

3.40%

发文量

309

审稿时长

3-8 weeks

期刊介绍： The Oncologist® is dedicated to translating the latest research developments into the best multidimensional care for cancer patients. Thus, The Oncologist is committed to helping physicians excel in this ever-expanding environment through the publication of timely reviews, original studies, and commentaries on important developments. We believe that the practice of oncology requires both an understanding of a range of disciplines encompassing basic science related to cancer, translational research, and clinical practice, but also the socioeconomic and psychosocial factors that determine access to care and quality of life and function following cancer treatment.