Cumulative genetic effects of HPA axis on social phobia scrutiny fear: psychoticism and social face as mediators.

IF 1.9 3区心理学 Q2 PSYCHIATRY

Anxiety Stress and Coping Pub Date : 2025-07-10 DOI:10.1080/10615806.2025.2530702

Yuting Yang, Wenting Liang, Wenping Zhao, Qi Lan, Mingzhu Zhou, Pingyuan Gong

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引用次数: 0

Abstract

Background: Social phobia scrutiny fear is a stress response triggered by perceptions of social evaluation. However, the role of genetic polymorphisms in the Hypothalamic Pituitary Adrenal (HPA) axis in shaping this fear is not well understood. This study investigates how the cumulative genetic score of the HPA axis influences social phobia scrutiny fear.

Method: Two independent samples were used. The first examined the relationship between the cumulative genetic effects of the HPA axis and social phobia scrutiny fear. The second sample replicated these findings and explored the mediating roles of psychoticism and social face.

Results: Both samples revealed that individuals with a higher cumulative genetic score, associated with increased cortisol reactivity, experienced greater social phobia scrutiny fear. Moreover, psychoticism and social face mediated this relationship, with a stronger genetic predisposition, higher psychoticism, and more pronounced social face correlating with greater scrutiny fear.

Conclusion: These findings highlight the significant role of the HPA axis in social phobia scrutiny fear and shed light on the psychological pathways through which genetic effects are influenced by personality traits.

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HPA轴对社交恐惧的累积遗传效应：精神病性和社交面孔作为中介。

背景：社交恐惧症审视恐惧是一种由社会评价感知引发的应激反应。然而，下丘脑垂体肾上腺（HPA）轴遗传多态性在形成这种恐惧中的作用尚未得到很好的理解。本研究探讨了HPA轴的累积遗传分数如何影响社交恐惧症的审查恐惧。方法：采用两个独立样本。第一项研究的是HPA轴的累积遗传效应与社交恐惧症之间的关系。第二个样本重复了这些发现，并探讨了精神病和社会面孔的中介作用。结果：两个样本都显示，累积基因得分较高的个体，与皮质醇反应性增加有关，经历了更大的社交恐惧症。此外，精神病和社会面孔介导了这种关系，更强的遗传倾向、更高的精神病和更明显的社会面孔与更大的审查恐惧相关。结论：这些发现突出了HPA轴在社交恐惧症审查恐惧中的重要作用，并揭示了遗传效应受人格特质影响的心理途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anxiety Stress and Coping Multiple-

CiteScore

7.20

自引率

0.00%

发文量

期刊介绍： This journal provides a forum for scientific, theoretically important, and clinically significant research reports and conceptual contributions. It deals with experimental and field studies on anxiety dimensions and stress and coping processes, but also with related topics such as the antecedents and consequences of stress and emotion. We also encourage submissions contributing to the understanding of the relationship between psychological and physiological processes, specific for stress and anxiety. Manuscripts should report novel findings that are of interest to an international readership. While the journal is open to a diversity of articles.