Neuroprotective effect of intravenous lipid emulsion after bupivacaine-induced cardiac toxicity.

IF 1.3 Q3 ANESTHESIOLOGY

Saudi Journal of Anaesthesia Pub Date : 2025-07-01 Epub Date: 2025-06-16 DOI:10.4103/sja.sja_810_24

Mevlüt Doğukan, Nezir Yılmaz, Ahmet Türk, Fadime Tosun, Mehmet Duran, Zeliha Bozkurt

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Abstract

Background: This study aimed to investigate the protective effects of intravenous lipid emulsion (ILE) against bupivacaine-induced cardiac toxicity, using histopathological analyses.

Methods: Twenty-eight adult male Wistar-Albino rats were divided into four groups: Sham (Group A), ILE (Group B), Bupivacaine (Group C), and Bupivacaine + ILE (Group D). Neurotoxicity was induced in Groups C and D with continuous bupivacaine infusion. ILE was administered to Groups B and D. Histological examination of brain tissues, and apoptotic index were evaluated.

Results: The apoptotic index was significantly higher in Group C, but ILE administration in Group D markedly decreased these parameters (P < 0.05). Histopathological analysis revealed that ILE reduced edema and neuronal degeneration in Group D.

Conclusion: ILE demonstrated a neuroprotective effect against bupivacaine-induced cardiac toxicity by improving hemodynamic stability and reducing cellular damage. This suggests a potential therapeutic role of ILE in managing local anesthetic systemic toxicity.

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静脉注射脂质乳对布比卡因心脏毒性后的神经保护作用。

背景：本研究旨在通过组织病理学分析，探讨静脉注射脂质乳（ILE）对布比卡因引起的心脏毒性的保护作用。方法：雄性Wistar-Albino成年大鼠28只，随机分为4组：假手术组（A组）、ILE组（B组）、布比卡因组（C组）、布比卡因+ ILE组（D组）。连续输注布比卡因引起神经毒性。B组和d组分别给予ILE，进行脑组织组织学检查，观察细胞凋亡指数。结果：C组细胞凋亡指数明显升高，D组细胞凋亡指数明显降低（P < 0.05）。组织病理学分析显示，ILE减轻了d组的水肿和神经元变性。结论：ILE通过改善血流动力学稳定性和减轻细胞损伤，对布比卡因引起的心脏毒性具有神经保护作用。这表明ILE在处理局麻全身毒性方面具有潜在的治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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